BRAIN STEM INTEGRATION OF CHEMORECEPTOR ACTIVITY

化学感受器活性的脑干整合

• 批准号: 3336163
• 负责人: Walter St. John
• 金额: $ 12.62万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-09-01 至 1990-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3336163
• 关键词: afferent nerve; brain stem; cats; chemical stimulation; chemoreceptors; electrical potential; electromyography; experimental brain lesion; hypoglossal nerve; innervation; microelectrodes; motor neurons; neural information processing; neuroanatomy; neuroeffector; neuropharmacology; peripheral nervous system; respiration regulatory center; respiratory airflow disorder; respiratory airway pressure; respiratory reflex; tongue; trigeminal nerve; vagotomy; vagus nerve

The overall goal is to describe the respiratory-related efferent activities of the hypoglossal and trigeminal nerves. These activities and those of muscles which they innervate in the oropharyngeal region have been shown to be important for maintaining upper airway patency, especially in sleep. Alterations in these neural or muscular activities or those of single hypoglossal and trigeminal neurons will be characterized in response to changes in chemoreceptor stimuli or elicitation of upper airway and/or pulmonary reflexes. Changes in these activities will also be analyzed following administration of pharmacological substances which differentially alter activities of the hypoglossal and trigeminal systems as compared to the bulbospinalphrenic system. It is hypothesized that these differential actions reflect a greater dependency for activites of hypoglossal and trigeminal neurons than bulbospinal neurons upon reticular formation processes. Data obtained will provide significant insights into mechanisms required for maintenance of upper airway patency. These data may have direct and immediate applications to the diagnosis and treatment of obstructive apneas in adults and children.

总体目标是描述与呼吸相关的传出活动 舌下神经和三叉神经。 这些活动以及 它们在口咽区域支配的肌肉已被证明 对于保持上呼吸道通畅很重要，尤其是在睡眠时。 这些神经或肌肉活动或单一活动的改变 舌下神经元和三叉神经元的特征是响应 化学感受器刺激或上呼吸道诱发的变化和/或 肺反射。 还将分析这些活动的变化 给予不同的药理学物质后 与相比，改变舌下神经和三叉神经系统的活动 球脊髓膈系统。 据推测，这些差异 动作反映了对舌下神经和舌下神经活动的更大依赖性 网状形成时三叉神经元比球脊髓神经元 流程。 获得的数据将为机制提供重要的见解 维持上呼吸道通畅所需。 这些数据可能有 直接立即应用于诊断和治疗 成人和儿童的阻塞性呼吸暂停。