EFFECT OF DIETARY MODIFICATION ON BLOOD PRESSURE CONTROL

这项研究的目的是解决长期未解决的问题- 持续治疗轻度高血压的长期治疗 参加降压试验的受试者的随访 干预和管理(TAIM)。塔伊姆是一个多中心的城市， 随机、安慰剂对照试验旨在评估 药理与饮食不同组合的有效性 轻度高血压的治疗干预(DBP 90-100) 毫米汞柱)。主要终点是血压变化在 基线和六个月。这项研究由3×3因素构成 受试者被随机分配到9种药物饮食的设计 治疗组。药物包括安慰剂、利尿剂和1β- 拦截者。饮食正常，减肥，低钠/高钠 钾(Na+/K+)。基本策略是解决临床问题 通过比较所选对象的平均舒张压变化来解决感兴趣的问题 减肥药组合。次要目标是评估 每种选择的组合：1)血清和尿液的变化 化学；2)生活质量指标和幸福感的变化 (包括副作用评估)，以及3)变化 心血管风险评分。 在初步的TAIM分析中，体重减轻似乎实质上 与正常饮食或Na+/K+饮食相比，6个月时的DBP较低。 在Na+/K+之间似乎没有血压差异 和平时的饮食小组。在TAIM(COTAIM)的延续中， 减肥组和随机选择一半的日常饮食 集团将在不变的情况下进行长期评估 减肥对控制轻度高血压的疗效。这个 减肥方案将添加到Na+/K+组和 其他随机选择的正常饮食组的一半在六个月内 评估可能的累加效应的月份注册期间 减肥和限钠与减肥的比较 独自一人。COTAIM建议评估这些措施的有效性 通过比较不同治疗方法在血液中的成功率 初步药物治疗中的压力控制。此外，在 选定对象的心血管风险评分和生活质量指数 将对抗高血压干预措施进行分析。几个时期 对于通常的减肥饮食，随访期平均为5年。 比较，包括TAIM随访，以及两年的 体重下降-体重下降/钠限制比较。

The aim of this study is to address unresolved issues in the long- term therapy of mild hypertension by continuing the treatment and follow-up of participants enrolled in the Trial of Antihypertensive Interventions and Management (TAIM). TAIM is a multicenter, randomized, placebo-controlled trial designed to assess the effectiveness of various combinations of pharmacologic and dietary interventions in the treatment of mild hypertension (DBP 90-100 mmHg). The primary endpoint is blood pressure change between baseline and six months. The study consists of a 3 X 3 factorial design wherein participants are randomly allocated to 9 drug-diet treatment groups. Drugs include placebo, diuretic and 1 beta- blocker. Diets are usual, weight loss and low sodium/high potassium (Na+/K+). The basic strategy is to address clinical questions of interest by comparing mean DBP changes of selected diet-drug combinations. Secondary objectives are to assess for each selected combination: 1) changes in serum and urine chemistries; 2) change in quality of life measures and well-being (including assessment of side effects), and 3) change in cardiovascular risk score. In preliminary TAIM analyses, weight loss appears to substantially lower DBP at 6 months when compared to a usual or Na+/K+ diet. There appear to be no blood pressure differences between the Na+/K+ and usual diet groups. In the continuation of TAIM (COTAIM), the weight loss group and a randomly selected half of the usual diet group are to be followed without change to evaluate the long-term efficacy of weight loss in the control of mild hypertension. The weight loss regimen is to be added to the Na+/K+ group and the other randomly selected half of the usual diet group during a six month enrollment period to evaluate possible additive effects of weight loss and sodium restriction in comparison to weight loss alone. COTAIM proposes to assess the effectiveness of these various treatments by comparing the proportion successful in blood pressure control on initial drug therapy. In addition, changes in cardiovascular risk scores and quality of life indices for selected antihypertensive interventions will be analyzed. The periods of follow-up will average about 5 years for the weight loss-usual diet comparison, including the TAIM follow-up, and 2 years for the weight loss-weight loss/sodium restriction comparison.