课题基金 / 基金详情

STUDIES OF SICKLING MECHANISMS AND RED CELL MEMBRANES

STUDIES OF SICKLING MECHANISMS AND RED CELL MEMBRANES
镰化机制和红细胞膜的研究
批准号：
3339441
负责人：
ROBERT M BOOKCHIN
金额：
$31.17万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1981
资助国家：
美国
项目状态：
已结题
起止时间：
1981-07-01 至 1986-09-29
来源：
https://reporter.nih.gov/project-details/3339441
关键词：
alkylating agents blood viscosity cell morphology crosslink erythrocyte membrane hemoglobin Ss hemoprotein structure human subject ionophores membrane permeability membrane structure mutant oxyhemoglobin pinocytosis polymerization sickle cell anemia sickling inhibitor ultracentrifugation

项目摘要

项目成果

ROBERT M BOOKCHIN的其他基金

相似基金

相关文献

中文摘要
翻译
提出的研究目的是：(1)进一步定义分子
英文摘要
The proposed research is aimed at (1) further definition of the molecular mechanisms of deoxy-Hb S polymerization and gelation, by mapping of intermolecular contact sites for each tetramer subunit, studies of the role of non S Hbs in polymerization, and the effect of Hb dissociation equilibria and hybrid formation in polymerization in red cells, and interactions of Hbs S and C; (2) further studies of functional properties of HbS-containing-red cells, (3) examination of the functional abnormalities (and their structural basis) of rbc membranes in SS, CC and other abnormal red cells. These studies are designed to further our knowledge of the mechanisms of sickling, to aid in the design and application of antisickling agents, to determine physiological conditions dangerous or favorable to persons with various sickling disorders, and to explore the pathophysiology of the red cell membranes with the overall aim of improving cell survival and function in these disorders.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Effects of Glycosylation on RBC Ca2+ Pump in Diabetes
Effects of Glycosylation on RBC Ca2+ Pump in Diabetes
BOOKCHIN
MOLECULAR AND RED CELL DETERMINANTS OF SICKLE CELL DISEASE
海外基金