CARDIAC ADENOSINE RECEPTORS

这个项目测试了腺苷假说的一些预测 是冠脉流量和心脏功能的生理调节器。 其中包括预测的嘌呤偶极矩和 外环嘌呤取代基与其立体选择性相互作用 冠状体内腺苷受体的特殊区域决定 腺苷的血管活性及茶碱的拮抗作用。这些研究 使用C2和C6取代的云杉碱以及N1和N3烷基黄嘌呤。 腺苷的抗N-g+构象与其结合的假设检验 该受体使用2英尺取代的2英尺脱氧腺苷。研究 检验假设，即存在地区差异的类型 腺苷R受体使用酶分散的心肌细胞和 腺苷类似物与右旋糖苷共价连接，以防止渗透到 细胞。

This project tests a number of predictions of the hypothesis that adenosine is a physiological regulator of coronary flow and cardiac performance. These include the predictions that the purine dipole moment and the stereoselective interaction of exocyclic purine substituents with specialized regions of the coronary adenosine receptor determine the vasoactivity of adenosines and antagonism by theophyllines. These studies employ C2 and C6 substituted nebularines and N1 and N3 alkylxanthines. Tests of the hypothesis that the anti-N-g+ conformer of adenosine binds to the receptor employs 2 feet-substituted 2 feet-deoxyadenosines. Studies testing the hypothesis that there are regional differences in the type of adenosine R receptors employ enzymatically dispersed cardiocytes and adenosine analogs covalently linked to dextrans to prevent penetration into cells.