THE EFFECT OF FISH OIL ON ATHEROSCLEROSIS IN VERVETS

一个由多学科研究人员组成的小组，他们在比较研究方面具有专长 医学、病理学、动脉粥样硬化、生物化学、脂类代谢和 中性粒细胞和血小板功能将寻求相关问题的答案 日粮鱼油对血脂、血小板和血脂的影响 中性粒细胞脂质成分和功能与动脉粥样硬化 马鞭草(Cercopithecus Acethiops)带或不带1夹2肾的动物 高血压患者饲喂含或不含鱼油的日粮2x2 析因实验。血小板聚集和血小板存活将是 量过了。二十碳五烯酸掺入细胞内的作用 环氧合酶和脂氧合酶途径产物上的膜将 在血小板和中性粒细胞中的研究以及对产生的影响 动脉注射前列环素。这些影响将与 花生四烯酸的产物。实验动物将被喂食 节食3年。鱼油的长期影响无论是有益的还是 将对不良反应进行评估，并确定动脉粥样硬化量 形态测量学上。短期研究和流行病学研究表明 这种鱼油应该对心血管疾病有有益的作用。 我们的长期目标是澄清任何有益或 并确定饲料中鱼油的最佳水平，以 以最小的负面影响获得最大的利益。

A multidisciplinary group of investigators with expertise in comparative medicine, pathology atherosclerosis, biochemistry, lipid metabolism, and neutrophil and platelet function will seek answers to pertinent questions about the effect of dietary fish oil on plama lipids, platelet and neutrophil lipid composition and function, and atherosclerosis in Cercopithecus acethiops (vervets). Animals with or without 1 clip 2 kidney hypertension will be fed diets with or without fish oil in a 2 x 2 factorial experiment. Platelet aggregation and platelet survival will be measured. The effect of incorporation of eicosapentaenoic acid into cell membranes on the products of cyclooxygenase and lipoxygenase pathways will be studied in platelets and neutrophils along with effects on production of prostacyclin by the artery. These effects will be compared to those of the products of arachidonic acid. The animals will be fed the experimental diets for 3 years. The long-term effects of fish oil either beneficial or adverse will be assessed, and the amount of atherosclerosis determined morphometrically. Short-term studies and epidemiologic studies suggest that fish oil should have a beneficial effect on cordiovascular disease. Our long-term objectives are to clarify the mechanisms of any beneficial or adverse effects and to determine the optimum level of dietary fish oil to obtain the greatest benefit with least adverse effect.