THE EFFECT OF FISH OIL ON ATHEROSCLEROSIS IN VERVETS

鱼油对长尾黑斑羚动脉粥样硬化的影响

• 批准号: 3341391
• 负责人: BILL C BULLOCK
• 金额: $ 8.33万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-04-01 至 1988-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3341391
• 关键词: atherosclerosis; blood coagulation tests; blood lipid; dietary lipid; fatty acid metabolism; marine animal oil; mass spectrometry; membrane lipids; neutrophil; nutrition related tag; omega 3 fatty acid; platelet aggregation; platelets; prostacyclins; radiotracer; unsaturated fatty acids

A multidisciplinary group of investigators with expertise in comparative medicine, pathology atherosclerosis, biochemistry, lipid metabolism, and neutrophil and platelet function will seek answers to pertinent questions about the effect of dietary fish oil on plama lipids, platelet and neutrophil lipid composition and function, and atherosclerosis in Cercopithecus acethiops (vervets). Animals with or without 1 clip 2 kidney hypertension will be fed diets with or without fish oil in a 2 x 2 factorial experiment. Platelet aggregation and platelet survival will be measured. The effect of incorporation of eicosapentaenoic acid into cell membranes on the products of cyclooxygenase and lipoxygenase pathways will be studied in platelets and neutrophils along with effects on production of prostacyclin by the artery. These effects will be compared to those of the products of arachidonic acid. The animals will be fed the experimental diets for 3 years. The long-term effects of fish oil either beneficial or adverse will be assessed, and the amount of atherosclerosis determined morphometrically. Short-term studies and epidemiologic studies suggest that fish oil should have a beneficial effect on cordiovascular disease. Our long-term objectives are to clarify the mechanisms of any beneficial or adverse effects and to determine the optimum level of dietary fish oil to obtain the greatest benefit with least adverse effect.

一个多学科的研究小组，具有比较 医学、病理学、动脉粥样硬化、生物化学、脂质代谢和 中性粒细胞和血小板功能将寻求相关问题的答案 关于鱼油对血脂、血小板和 中性粒细胞脂质组成和功能与动脉粥样硬化 Cercopithecus acethiops（长尾猴）。 带或不带1夹2肾的动物 高血压患者将被喂食含有或不含鱼油的饮食， 析因实验 血小板聚集和血小板存活率将是 测定了 二十碳五烯酸掺入细胞的作用 环氧化酶和脂氧合酶途径产物上的膜将 在血小板和嗜中性粒细胞中进行了研究，沿着研究了对 前列环素 这些影响将与 花生四烯酸的产物。 这些动物将被喂食实验性的 三年的饮食。 鱼油的长期效果是有益的， 将评估不良反应，并确定动脉粥样硬化的量 形态计量学 短期研究和流行病学研究表明， 鱼油应该对心血管疾病有有益的影响。 我们的长期目标是澄清任何有益的或 副作用，并确定膳食鱼油的最佳水平， 以最小的负面影响获得最大的利益。