MULTINUCLEAR NMR IMAGING OF REGIONAL LUNG WATER

肺水肿是左心室最常见的并发症之一。 失败了。通常由呼吸困难等症状提示，并诊断为 通过胸部听诊或X光照相。它经常是相对的 在它可以被可靠地检测到之前，它是非常先进的。从放射学上讲，它是 难以与炎性或其他肺浸润性疾病相鉴别 在许多患者中，肺水肿与感染的鉴别 对于治疗的选择来说，可能是困难和关键的。 核磁共振T1和T2弛豫时间对 总的自由组织水，应该与自旋密度无关 每单位体积。如果是这样的话，它们可以用来测量肺水。 水肿液是含钠离子浓度的血浆的超滤液。 类似于等离子体。因此，增加胞外水分应该是 可通过钠信号强度的增加来测量。 通过使用限制在血管隔间中的顺磁剂 测量血液t1和总t1，就可以计算 生理状态下血管外室的T1 车厢之间的扩散是“快速的”。 水肿往往是片状的，经常占据依赖的部分 优先选择肺部。一种成像方法的优点 衡量是，它可以解释不均匀的分布 浮肿。根据图像进行的区域测量将直接与 通过重力测量来确定该方法的准确性。 这将在1.4特斯拉的动物成像系统中使用动物进行研究 肺不张、通透性水肿和血流动力学水肿模型。

Pulmonary edema is one of the most common complications of left ventricular failure. It is typically suggested by symptoms like dyspnea and diagnosed by auscultation of the chest or radiography. It is frequently relatively far advanced before it can be reliably detected. Radiographically, it is difficult to distinguish from inflammatory or other pulmonary infiltrates and in many patients the discrimination of pulmonary edema from infection can be difficult and pivotal for the choice of therapy. The nuclear magnetic resonance T1 and T2 relaxation times are sensitive to the total free tissue water and should be independent of the spin density per unit volume. If so, they can be used for measuring lung water. Edema fluid is an ultrafiltrate of plasma with a sodium ion concentration similar to plasma. Therefore, increased extracellular water should be measurable as an increase in sodium signal intensity. By using a paramagnetic agent that is confined to the vascular compartment and measuring the blood T1 and the total T1, it will be possible to compute the T1 of the extravascular compartment in physiologic situations where diffusion between compartments is "fast." Edema tends to be patchy, frequently occupying the dependent portions of the lungs preferentially. An advantage of an imaging method for measurement is that it can account for the nonhomogeneous distribution of edema. Regional measurements made from images will be compared directly to gravimetric measurements to determine the accuracy of the method. This will be studied in a 1.4 Tesla animal imaging system using animal models for atelectasis permeability edema and hemodynamic edema.