MULTINUCLEAR NMR IMAGING OF REGIONAL LUNG WATER

区域肺水的多核核磁共振成像

• 批准号: 3346368
• 负责人: HAROLD L. KUNDEL
• 金额: $ 15.26万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1989-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3346368
• 关键词: atelectasis; disease /disorder model; extracellular; laboratory rabbit; laboratory rat; lung; magnetic resonance imaging; mathematical model; pulmonary edema; respiratory disorder diagnosis; sodium

Pulmonary edema is one of the most common complications of left ventricular failure. It is typically suggested by symptoms like dyspnea and diagnosed by auscultation of the chest or radiography. It is frequently relatively far advanced before it can be reliably detected. Radiographically, it is difficult to distinguish from inflammatory or other pulmonary infiltrates and in many patients the discrimination of pulmonary edema from infection can be difficult and pivotal for the choice of therapy. The nuclear magnetic resonance T1 and T2 relaxation times are sensitive to the total free tissue water and should be independent of the spin density per unit volume. If so, they can be used for measuring lung water. Edema fluid is an ultrafiltrate of plasma with a sodium ion concentration similar to plasma. Therefore, increased extracellular water should be measurable as an increase in sodium signal intensity. By using a paramagnetic agent that is confined to the vascular compartment and measuring the blood T1 and the total T1, it will be possible to compute the T1 of the extravascular compartment in physiologic situations where diffusion between compartments is "fast." Edema tends to be patchy, frequently occupying the dependent portions of the lungs preferentially. An advantage of an imaging method for measurement is that it can account for the nonhomogeneous distribution of edema. Regional measurements made from images will be compared directly to gravimetric measurements to determine the accuracy of the method. This will be studied in a 1.4 Tesla animal imaging system using animal models for atelectasis permeability edema and hemodynamic edema.

肺水肿是左心室肥厚最常见的并发症之一 失败 它通常由呼吸困难等症状提示， 通过胸部听诊或放射线照相术。 它经常相对 在它被可靠地检测到之前就已经很先进了。 从放射学上看， 难以与炎性或其他肺部浸润区分 在许多患者中，肺水肿与感染的区分 可能是治疗选择的难点和关键。 核磁共振T1和T2弛豫时间对 总的游离组织水，并且应该与自旋密度无关 每单位体积。 如果是这样，它们可以用于测量肺水。 水肿液是血浆的超滤液，其钠离子浓度 类似于Plasma。 因此，增加的细胞外水应该是 可测量为钠信号强度的增加。 通过使用局限于血管室的顺磁剂 测量血液T1和总T1，可以计算出 在生理情况下血管外室的T1， 隔室之间的扩散是“快速的”。" 水肿往往是斑片状的，经常占据的依赖部分， 肺优先。 一种成像方法的优点在于， 它可以解释非均匀分布， 水肿 从图像中进行的区域测量将直接与 重量分析测量以确定该方法的准确度。 这将在1.4特斯拉的动物成像系统中使用动物模型进行研究。 肺不张通透性水肿和血流动力学水肿模型。