SERUM CHOLESTEROL, BLOOD PRESSURE, AND MORTALITY

有11,320名男性的数据，年龄最初在40-59岁，没有证据表明 心血管疾病，建议分析 某些条目特征以及在这些特征和 冠心病、癌症和各种原因造成的死亡。这些人组成了15个军团 芬兰、希腊、意大利、日本、荷兰、美国和 南斯拉夫在地理上占所有13岁男子的90%以上 确定的区域和铁路中的特定职业和位置 美国和意大利的工业。在15年内，其中2136人 男性死亡；603人死于癌症，561人死于冠心病，死亡人数 在队列和地区之间差异很大。 需要注意的特征是相对体重(体重指数)， 由高度、双肩峰和双眼球结节直径表示的“框架”， 肥胖由皮脂厚度、血压、血清胆固醇、 和吸烟习惯。这些特征之间的相互关系和 它们与死亡率之间的关系将由队列和 一群群的人。重点将放在没有假设的方法上 关于关系的形式和变量的分布。 据信，这些分析将发现曲线和线性 关系，并指示关系的相似程度 在生活方式和其他特征上不同的人群。结果是 在考虑可能的预防计划时应该很有用。它 认识到这些目标可能不会在有限的时间内完全实现 提议的，但可以承诺取得重要进展，因为数据在 以可访问的形式提交，分析需求已被理解，并进行了大量工作 申请人已对此材料所做的工作表明将使用的方法 以及追寻的方向。

With data on 11,320 men initially aged 40-59 and without evidence of cardiovascular disease, it is proposed to analyze interrelationships among certain entry characteristics and between those characteristics and coronary, cancer, and all-causes deaths. The men form 15 cohorts in Finland, Greece, Italy, Japan, the Netherlands, the United States, and Yugoslavia comprising over 90% of all men of the age of 13 geographically defined areas and in specified occupations and locations in the railroad industry in the United States and in Italy. In 15 years, 2,136 of those men died; 603 from cancer, 561 from coronary heart disease, and mortality varied markedly among cohorts and regions. Characteristics for attention are relative weight (body mass index), "frame" indicated by height and bi-acromial and bi-cristal diameters, fatness indicated by skinfold thickness, blood pressure, serum cholesterol, and smoking habit. Inter-relationships among these characteristics and relationships between them and mortality will be examined by cohorts and groups of cohorts. Emphasis will be put on methods without assumptions about the form of the relations and the distributions of the variables. It is believed the analyses will find curvilinear as well as linear relationships and indicate the extent to which relationships are similar in populations differing in mode of life and other features. The results should be useful in the consideration of possible preventive programs. It is realized that the goals may not be fully attained in the limited period proposed, but important progress can be promised because the data are at hand in accessible form, the analytical needs are understood, and much work already done on this material by the applicant indicates methods to be used and directions to pursue.