TREATMENT OF MILD HYPERTENSION STUDY (TOMHS)

轻度高血压的治疗研究 (TOMHS)

• 批准号: 3348067
• 负责人: Richard Hugo Grimm
• 金额: $ 193.1万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 1992-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3348067
• 关键词: ACE inhibitors; alcoholic beverage consumption; alpha antiadrenergic agent; antihypertensive agents; behavior modification; beta antiadrenergic agent; blood chemistry; blood pressure; calcium channel blockers; cardiovascular disorder chemotherapy; cardiovascular disorder prevention; diuretics; drug adverse effect; echocardiography; electrocardiography; enalapril; exercise; heart dimension /size; human middle age (35-64); human subject; hypertension; low salt diet; myocardial ischemia /hypoxia; nutrition related tag; questionnaires; statistics /biometry; therapy compliance; urinalysis; weight control

This proposal is for the renewal for Phase I of the Treatment of "Mild" Hypertension Study (T0MHS). The study will allow for long-term detailed assessment of 902 hypertensives prescribed one of five active drugs (representing major classes of medications currently in use) or placebo, using a randomized double-blind design. Each treatment group also is advised nonpharmacologic methods to control their blood pressure including weight loss, dietary sodium reduction, alcohol reduction and increased leisure-time physical activity. This proposal is for a 2 year and 7 month continuation which includes 2 additional years of follow-up and a final 7 months for close-out activities, data analysis and publications.

本建议是为第一阶段治疗“轻度” 高血压研究（T0MHS）。 这项研究将允许长期详细的 评估902名高血压患者处方的五种活性药物之一 （代表目前使用的主要药物类别）或安慰剂， 采用随机双盲设计。 每个治疗组也是 建议采用非药物方法控制血压，包括 体重减轻，饮食钠减少，酒精减少和增加 休闲时间的体育活动。 本提案为期2年零7个月 持续，包括额外2年的随访和最后7年 用于收尾活动、数据分析和出版物的时间。