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TREATMENT OF MILD HYPERTENSION STUDY (TOMHS)

TREATMENT OF MILD HYPERTENSION STUDY (TOMHS)
轻度高血压的治疗研究 (TOMHS)
批准号：
3348067
负责人：
Richard Hugo Grimm
金额：
$193.1万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
1990
资助国家：
美国
项目状态：
已结题
起止时间：
1990-09-30 至 1992-09-29
来源：
https://reporter.nih.gov/project-details/3348067
关键词：
ACE inhibitors alcoholic beverage consumption alpha antiadrenergic agent antihypertensive agents behavior modification beta antiadrenergic agent blood chemistry blood pressure calcium channel blockers cardiovascular disorder chemotherapy cardiovascular disorder prevention diuretics drug adverse effect echocardiography electrocardiography enalapril exercise heart dimension /size human middle age (35-64) human subject hypertension low salt diet myocardial ischemia /hypoxia nutrition related tag questionnaires statistics /biometry therapy compliance urinalysis weight control

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中文摘要
翻译
本建议是为第一阶段治疗“轻度” 高血压研究（T0MHS）。 这项研究将允许长期详细的 评估902名高血压患者处方的五种活性药物之一 （代表目前使用的主要药物类别）或安慰剂， 采用随机双盲设计。 每个治疗组也是 建议采用非药物方法控制血压，包括 体重减轻，饮食钠减少，酒精减少和增加 休闲时间的体育活动。 本提案为期2年零7个月 持续，包括额外2年的随访和最终7年的随访 用于收尾活动、数据分析和出版物的时间。
英文摘要
This proposal is for the renewal for Phase I of the Treatment of "Mild" Hypertension Study (T0MHS). The study will allow for long-term detailed assessment of 902 hypertensives prescribed one of five active drugs (representing major classes of medications currently in use) or placebo, using a randomized double-blind design. Each treatment group also is advised nonpharmacologic methods to control their blood pressure including weight loss, dietary sodium reduction, alcohol reduction and increased leisure-time physical activity. This proposal is for a 2 year and 7 month continuation which includes 2 additional years of follow-up and a final 7 months for close-out activities, data analysis and publications.
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