FAMILIAL HYPERTENSION & BIRACIAL CV REACTIVITY IN YOUTH

原发性高血压(EH)在美国是一个主要的健康问题； 它在黑人人群中尤其普遍。尝试说明 对于EH中的种族差异，已经尝试应用风险因素 方法，在这种方法中，肥胖、吸烟、酒精摄入量、 久坐的生活方式、饮食历史和遗传被认为是有关联的。 直接导致了这种差异。人们普遍认为，减少 风险因素是任何EH预防计划的主要目标。一个 越来越多的证据支持这样一个概念，即心血管疾病 反应性是一个标志，可能本身就是一个重要的风险因素。 对，在EH的演变中。到目前为止，只有有限的数据可以 解决心血管反应对心理和/或的不同 黑人和白人之间的身体挑战。我们已经证明了 心血管对生理和心理压力的反应不同 在健康的黑人儿童和白人儿童之间。 这项研究的目标是在2(受试者的种族)×2(性别)的情况下评估 受试者)x 3(父母高血压状况)设计如下：1) 对应激刺激的反应差异：心理、身体和 《日常生活》2)A/B型行为成分的影响 维度，3)心血管反应与代谢的关系， 酶和饮食测量，包括血浆肾素、钙离子、钠离子 摄入量和排泄量与红细胞Na~+-K~+-ATPase，4)膳食效应 Na+，K+，Ca++，NaC l和安慰剂的负荷对反应性，代谢， 和酶的测量。 这项研究的结果可能证明开发新的诊断方法是合理的。 对潜在重要性进行简单、非侵入性评估的程序 风险因素。这些新程序可以合并到一个计划中 预防性心脏病筛查和可能的前瞻性干预 学习。

Essential hypertension (EH) is a major health concern in the United States; it is especially prevalent in the black population. Attempts to account for the racial difference in EH have tried to apply the risk factor approach, in which variables such as obesity, smoking, alcohol intake, sedentary lifestyle, dietary history, and heredity are presumed to relate directly to this difference. It is generally agreed that the reduction of risk factors is the major goal of any program for the prevention of EH. An increasing body of evidence supports the concept that cardiovascular reactivity is a marker, and possibly an important risk factor in its own right, in the evolution of EH. To date, there are limited data which address differences in cardiovascular reactivity to psychologic and/or physical challenge between blacks and whites. We have demonstrated that cardiovascular reactivity to physical and psychologic stress does differ between groups of healthy black children and white children. The objectives of this study are to assess in a 2(race of subject) x 2(sex of subject) x 3(parental hypertension status) design the following: 1) differences in responses to stressful stimuli: psychologic, physical, and "everyday life," 2) effects of the components of the Type A/B behavior dimension, 3) relation of cardiovascular reactivity to metabolic, enzymatic, and dietary measurements, including plasma renin, Ca++, Na+ intake and excretion, and erythrocyte Na+ K+-ATPase, 4) effects of dietary loading of Na+, K+, Ca++, NaCl, and placebo upon the reactivity, metabolic, and enzymatic measurements. The results of this study may justify the development of new diagnostic procedures for the simple, non-invasive assessment of potentially important risk factors. These new procedures could be incorporated into a program of preventive cardiology screening and possibly prospective intervention studies.