APPLICATIONS OF PHARMACOKINETICS IN CLINICAL PSYCHIATRY

药代动力学在临床精神病学中的应用

• 批准号: 3375512
• 负责人: RICHARD I SHADER
• 金额: $ 36.82万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-09-15 至 1986-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3375512
• 关键词: drug metabolism; human subject; mental disorder chemotherapy; psychopharmacology

Stated briefly, our objectives are as follows: a) to investigate changes in drug metabolism associated with the aging process by delineating the relative importance and interrelationships of selected pathways (e.g., dealkylation, hydroxylation, glucuronidation) in older persons taking specific (model) benzodiazepines selected to illuminate each pathway. Younger adults will be studied for comparative purposes; b) to determine blood levels for bqnzodiazepines in patients receiving emergency room care for benzodiazepine overdosage; to assess the relationship between blood levels and morbidity; and to evaluate the usefulness of these levels for clinical care and treatment planning; c) to continue our studies of drug interactions; d) to investigate the development of tolerance (physiological) to benzodiazepines by studying changing threshholds to amobarbital-induced bilateral gaze nystagmus in subjects taking benzodiazepines for varying amounts of time; e) to continue to improve the practicing clinician's understanding of rational therapeutic approaches by extending our educational efforts in clinical psychopharmacology.

简而言之，我们的目标如下：a)调查 通过描绘与衰老过程相关的药物代谢 所选途径的重要性和相互关系(例如，脱烷基化， 羟化、葡萄糖醛酸化)在老年人服用特定(模型) 选择苯二氮卓类药物来照亮每一条途径。年轻的成年人将成为 为了比较的目的而研究；b)测定血液水平 苯二氮类药物在急诊室接受苯二氮卓类药物治疗中的应用 过量用药；评估血液水平与发病率的关系；以及 评估这些水平对临床护理和治疗的有用性。 计划；c)继续研究药物相互作用；d)调查 通过研究变化发展对苯二氮卓类药物的耐受性(生理) 服药受试者异巴比妥诱发双眼注视眼球震颤的阈值 服用苯二氮卓类药物的时间长短不一；e)继续改善 实践临床医生对合理治疗方法的理解 扩大我们在临床精神药理学方面的教育努力。