APPLICATIONS OF PHARMACOKINETICS IN CLINICAL PSYCHIATRY

简而言之，我们的目标如下：a）调查 药物代谢与衰老过程相关，通过描绘相对 所选途径的重要性和相互关系（例如，脱烷基化， 羟基化，葡萄糖醛酸化）在老年人服用特定（模型） 苯二氮卓类药物来阐明每种途径。 年轻的成年人将 为了比较的目的而研究; B）测定血液中 因苯二氮卓类药物接受急诊室护理的患者中的苯二氮卓类药物 过量;评估血液水平与发病率之间的关系;以及 评估这些水平对临床护理和治疗的有用性 计划; c）继续我们对药物相互作用的研究; d）调查 通过研究苯二氮卓类药物的变化， 受试者中异戊巴比妥诱导的双侧凝视眼震的阈值 苯并二氮杂卓类药物治疗不同的时间; e）继续改善 实践临床医生对合理治疗方法的理解， 扩展我们在临床精神药理学方面的教育努力。

Stated briefly, our objectives are as follows: a) to investigate changes in drug metabolism associated with the aging process by delineating the relative importance and interrelationships of selected pathways (e.g., dealkylation, hydroxylation, glucuronidation) in older persons taking specific (model) benzodiazepines selected to illuminate each pathway. Younger adults will be studied for comparative purposes; b) to determine blood levels for bqnzodiazepines in patients receiving emergency room care for benzodiazepine overdosage; to assess the relationship between blood levels and morbidity; and to evaluate the usefulness of these levels for clinical care and treatment planning; c) to continue our studies of drug interactions; d) to investigate the development of tolerance (physiological) to benzodiazepines by studying changing threshholds to amobarbital-induced bilateral gaze nystagmus in subjects taking benzodiazepines for varying amounts of time; e) to continue to improve the practicing clinician's understanding of rational therapeutic approaches by extending our educational efforts in clinical psychopharmacology.