ROLE OF BIOGENIC AMINES IN THE CENTRAL NERVOUS SYSTEM

本研究的目的是阐明DA激动剂和拮抗剂诱导 突触前和突触后DA神经元系统的变化。这些研究将是 重点研究了以下几个方面：1)TH活性的机制和激活 C-AMP依赖的蛋白激酶系统；2.酪氨酸的调节 特异性DA受体的羟基酶活性3.酶的纯化 参与单胺生物合成。这些酶的性质将是 鉴定和纯化的酶将用于生产特定的 抗血清。4.肾上腺素的生化和形态相互作用 神经系统和其他单胺能系统将被研究。5.方法 将被开发用于表征和纯化多个DA 感受器。6.多巴胺激动剂和拮抗剂慢性治疗的效果 将对突触前和突触后神经系统进行研究。 我们希望我们的研究结果将为生物化学提供新的见解。 在治疗精神和神经疾病过程中发生的变化 DA拮抗剂和激动剂。

The purpose of this study is to elucidate DA agonists and antagonists induced changes in pre- and postsynaptic DA neuronal systems. These studies will be focused on the following areas: 1) The mechanisms and activation of TH activity by c-AMP dependent protein kinase systems; 2. The regulation of tyrosine hydroxylase activity by specific DA receptors 3. The purification of enzymes involved in monoamine biosynthesis. The properties of these enzymes will be characterized and purified enzymes will be utilized for production of specific antisera. 4. The biochemical and morphological interaction of the Epinephrine neuronal systems with other monoaminergic systems will be studied. 5. Methods will be developed for characterization and purification of multiple DA receptors. 6. The effect of chronic treatment with DA agonists and antagonists on pre- postsynaptic neuronal systems will be investigated. We hope that the results of our study will provide new insight on biochemical changes which occur during treatments of mental and neurological disorders with DA antagonists and agonists.