BLOOD DONATIONS IN THE ELDERLY

老年人献血

• 批准号: 3350886
• 负责人: TOBY L SIMON
• 金额: $ 14.1万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-04-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3350886
• 关键词: blood chemistry; blood donor; blood pressure; blood tests; body physical activity; cardiovascular disorder diagnosis; cardiovascular function; diet; disease /disorder proneness /risk; electrocardiography; health; human old age (65+); human subject; iron disorder; longitudinal human study; questionnaires; self concept; social behavior; urinalysis

In the past, age 65 was considered a logical point at which to stop taking blood donations. However, there is little evidence to support this decision especially if there are no overt health problems that would compromise these individuals if they were regular blood donors. The primary aim of this study is to assess whether healthy elderly between 63 and 70 years of age at entry into this 5 year study can donate blood 4 to 5 times per year with no risk to their health status. This issue may become quite important in certain areas of the country where the elderly are increasing in numbers relative to the younger population. Adequate supplies of blood may depend of their ability to contribute. Two hundred healthy elderly volunteers (100 males and 100 females) will be recruited and randomly assigned into two groups. Group 1 (50 males and 50 females) will donate blood regularly every 8-12 weeks. Group 2 (50 males and 50 females) will serve as the control population and will be required to provide the same information as Group 1 except for donating blood. Both groups will receive yearly physical exams and an in depth laboratory screen (SMAC-24, CBC's and iron assessment) which will allow us to determine changes in health status in these individuals during the 5 year period. We will simultaneously assess sense of self worth and worth to one's community by interview. Also, each individual will have yearly non invasive cardiac studies (EKG, Echo and Pulse Doppler). Concern about creating iron deficiency problems in the blood donating group will be minimal as these individuals will be monitored at each donation using laboratory measurements to assess iron status; i.e. hemoglobin, plasma iron, TIBC and ferritin. Longitudinal and group comparisons will be made using physical exam information, quantative self-esteem inventory, and cardiovascular parameters.

在过去，65岁被认为是一个逻辑点， 接受献血 然而，几乎没有证据表明， 支持这一决定，特别是如果没有明显的健康 这些问题会危及这些人，如果他们是 定期献血者 本研究的主要目的是评估 入境时年龄介乎63至70岁的健康长者， 在这项为期5年的研究中，每年可以献血4到5次， 对他们的健康状况没有风险。 这个问题可能会变得相当 在一些老年人居住的地区， 相对于年轻人口而言，数量有所增加。 充足的血液供应可能取决于他们的能力， 贡献. 健康老年志愿者200名（男性100名 和100名女性）将被招募并随机分配到两个 组 第1组（50名男性和50名女性）将献血 定期每8-12周。 第2组（50只雄性和50只雌性） 将作为控制人口，并将被要求提供 除献血外，其他信息与第1组相同。 两 团体将接受年度体检和深入的 实验室筛查（SMAC-24、CBC和铁评估）， 将使我们能够确定这些人健康状况的变化， 个人在5年期间。 我们将同时 评估自我价值感和对社区的价值感， 采访 此外，每个人每年将有非侵入性 心脏检查（EKG、回波和脉冲多普勒）。 关切 在献血人群中造成缺铁问题， 因为这些人将在每次捐赠时受到监测， 使用实验室测量来评估铁状态;即， 血红蛋白、血浆铁、TIBC和铁蛋白。 纵向和 将使用体检信息进行组比较， 定量自尊量表和心血管参数。