SOCIAL STATUS AND ATHEROSCLEROSIS IN FEMALES

而冠心病(CHD)是导致死亡的主要原因 在60岁以上的女性中，这一领域的研究还很缺乏， 尤其是关于心理社会危险因素，关系 心理社会因素和其他危险因素之间的关系，以及 心理社会危险因素修正。 拟议研究的主要目标是确定 心理社会危险因素是否改变以及改变到什么程度 能有效降低饮食引起的动脉粥样硬化的风险 雌性猴子。 其他具体目标包括对 动脉粥样硬化与社会地位的关系 先前观察到的与以下因素相关的心理社会变量 动脉粥样硬化；以及之间关系的描绘 社会地位和其他风险因素。由此生成的数据 实验将增加心理社会风险的基本知识 女性冠心病的危险因素，并可能与 心理社会风险临床试验的设计与实施 因子修改。 这项拟议的实验需要48只成年雌性食蟹鱼 猕猴(猕猴)，喂食致动脉粥样硬化的食物和生活 以四只动物为一组的群居动物。实验操作 将产生四个群体：1)在社会上占主导地位的女性 在操纵前后，2)占优势的女性 手法前和手法后从属；3)女性 操作前从属，操作后主导；4) 雌性在操纵前后处于从属地位。 动脉粥样硬化与相关行为学指标的比较 不同组之间的临床病理风险变量将提供关于 心理社会危险因素改良的相对疗效。

While coronary heart disease (CHD) is the leading cause of death in women beyond age 60, research in the area is lacking, especially concerning psychosocial risk factors, the relationship between psychosocial and other risk factors, and the efficacy of psychosocial risk factor modification. The major objective of the proposed research is to determine whether and to what extent psychosocial risk factor modification is effective in reducing the risk of diet-induced atherosclerosis in female monkeys. Other specific aims include the characterization of the nature of the relationship between atherosclerosis and social status, a psychosocial variable previously observed to be associated with atherosclerosis; and the delineation of relationships between social status and other risk factors. Data produced by this experiment will increase basic knowledge of psychosocial risk factors of CHD in females, and may have a direct bearing on the design and implementation of clinical trials of psychosocial risk factor modification. The proposed experiment requires 48 adult female cynomolgus macaques (Macaca fascicularis), fed an atherogenic diet and living in social groups of four animals each. Experimental manipulation will result in four groups: 1) females that are socially dominant before and after the manipulation, 2) females that are dominant before and subordinate after manipulation, 3) females that are subordinate before and dominant after manipulation, and 4) females that are subordinate before and after manipulation. Comparison of atherosclerosis and related behavioral and clinicopathologic risk variables among groups will provide data on the relative efficacy of psychosocial risk factor modification.