SOCIAL STATUS AND ATHEROSCLEROSIS IN FEMALES

虽然冠心病（CHD）是导致死亡的主要原因 对于 60 岁以上的女性，该领域的研究还很缺乏， 尤其是在心理社会风险因素方面，这种关系 心理社会因素和其他危险因素之间的关系，以及治疗效果 社会心理危险因素修正。 拟议研究的主要目标是确定 是否以及在多大程度上改变社会心理危险因素 能有效降低饮食引起的动脉粥样硬化的风险 母猴。 其他具体目标包括表征 动脉粥样硬化与社会地位之间的关系 先前观察到的心理社会变量与 动脉粥样硬化;以及之间关系的描述 社会地位和其他危险因素。 由此产生的数据 实验将增加心理社会风险的基本知识 女性冠心病的发病因素，可能与 心理社会风险临床试验的设计和实施 因素修改。 拟议的实验需要 48 只成年雌性食蟹猴 猕猴（Macaca fasciculis），喂食致动脉粥样硬化饮食并生活 每组有四只动物。 实验操作 将产生四个群体：1）在社会上占主导地位的女性 操纵前后，2）占主导地位的女性 操作前和操作后从属，3）女性 操纵前为从属，操纵后为主导，4) 在操纵之前和之后都处于从属地位的女性。 动脉粥样硬化与相关行为和行为的比较 各组之间的临床病理风险变量将提供以下数据： 心理社会危险因素修正的相对功效。

While coronary heart disease (CHD) is the leading cause of death in women beyond age 60, research in the area is lacking, especially concerning psychosocial risk factors, the relationship between psychosocial and other risk factors, and the efficacy of psychosocial risk factor modification. The major objective of the proposed research is to determine whether and to what extent psychosocial risk factor modification is effective in reducing the risk of diet-induced atherosclerosis in female monkeys. Other specific aims include the characterization of the nature of the relationship between atherosclerosis and social status, a psychosocial variable previously observed to be associated with atherosclerosis; and the delineation of relationships between social status and other risk factors. Data produced by this experiment will increase basic knowledge of psychosocial risk factors of CHD in females, and may have a direct bearing on the design and implementation of clinical trials of psychosocial risk factor modification. The proposed experiment requires 48 adult female cynomolgus macaques (Macaca fascicularis), fed an atherogenic diet and living in social groups of four animals each. Experimental manipulation will result in four groups: 1) females that are socially dominant before and after the manipulation, 2) females that are dominant before and subordinate after manipulation, 3) females that are subordinate before and dominant after manipulation, and 4) females that are subordinate before and after manipulation. Comparison of atherosclerosis and related behavioral and clinicopathologic risk variables among groups will provide data on the relative efficacy of psychosocial risk factor modification.