SOCIAL STATUS AND ATHEROSCLEROSIS IN FEMALES

女性的社会地位和动脉粥样硬化

• 批准号: 3356681
• 负责人: Carol A. Shively
• 金额: $ 13.1万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3356681
• 关键词: Macaca fascicularis; atherosclerosis; cardiovascular disorder epidemiology; disease /disorder proneness /risk; female; psychological stressor; social dominance; social status

While coronary heart disease (CHD) is the leading cause of death in women beyond age 60, research in the area is lacking, especially concerning psychosocial risk factors, the relationship between psychosocial and other risk factors, and the efficacy of psychosocial risk factor modification. The major objective of the proposed research is to determine whether and to what extent psychosocial risk factor modification is effective in reducing the risk of diet-induced atherosclerosis in female monkeys. Other specific aims include the characterization of the nature of the relationship between atherosclerosis and social status, a psychosocial variable previously observed to be associated with atherosclerosis; and the delineation of relationships between social status and other risk factors. Data produced by this experiment will increase basic knowledge of psychosocial risk factors of CHD in females, and may have a direct bearing on the design and implementation of clinical trials of psychosocial risk factor modification. The proposed experiment requires 48 adult female cynomolgus macaques (Macaca fascicularis), fed an atherogenic diet and living in social groups of four animals each. Experimental manipulation will result in four groups: 1) females that are socially dominant before and after the manipulation, 2) females that are dominant before and subordinate after manipulation, 3) females that are subordinate before and dominant after manipulation, and 4) females that are subordinate before and after manipulation. Comparison of atherosclerosis and related behavioral and clinicopathologic risk variables among groups will provide data on the relative efficacy of psychosocial risk factor modification.

虽然冠心病是导致死亡的主要原因， 在60岁以上的妇女中，缺乏这方面的研究， 特别是关于心理社会风险因素， 社会心理因素和其他风险因素之间的关系，以及 心理社会风险因素修正 本研究的主要目的是确定 是否以及在多大程度上改变了心理社会风险因素 有效降低饮食引起的动脉粥样硬化的风险， 母猴子 其他具体目标包括： 动脉粥样硬化和社会地位之间的关系， 先前观察到的与以下因素相关的社会心理变量 动脉粥样硬化;以及 社会地位和其他风险因素。 由此产生的数据 实验将增加心理社会风险的基本知识 女性冠心病的因素，并可能有直接关系， 心理社会风险临床试验的设计和实施 因子修正 拟议的实验需要48只成年雌性食蟹猴 食蟹猴（Macaca fascicularis），喂食致动脉粥样硬化饮食， 每四只动物组成一个群体。 实验操作 将导致四组：1）女性是社会主导 操作前后，2）占主导地位的女性 前和下属后操纵，3）女性是 在操纵之前处于从属地位，在操纵之后处于主导地位，以及4） 女性在被操纵之前和之后都处于从属地位。 动脉粥样硬化与相关行为和心血管疾病的比较 组间临床病理风险变量将提供以下数据： 心理社会危险因素修正的相对有效性。