INFLAMMATORY INJURY OF LUNG ALVEOLAR EPITHELIAL CELLS

肺泡上皮细胞炎症损伤

基本信息

  • 批准号:
    3356734
  • 负责人:
  • 金额:
    $ 13.76万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1988
  • 资助国家:
    美国
  • 起止时间:
    1988-07-01 至 1991-06-30
  • 项目状态:
    已结题

项目摘要

The alveolar injury that occurs in the adult respiratory distress syndrome (ARDS) appears in many cases to be secondary to activation of inflammatory processes, particularly those involving neutrophils and/or oxygen metabolites. Injury of alveolar epithelial cells has been found to be a prominent, early feature of ARDS. Because the integrity of the alveolar epithelium is critical in preventing fluid from accumulating within the alveolar compartment, and because the alveolar epithelium has received relatively little study compared to the vascular endothelium, this proposal contains experiments designed to study the mechanisms by which stimulated neutrophils and/or oxygen metabolites can injure lung epithelial cells. The hypotheses are: that abberations in ATP metabolism are intimately involved in the process of injury; that the susceptibility of target cells to neutrophil-induced injury is dependent upon their ability to detoxify oxidants; and that epithelial cell membrane injury is a prominent, early feature of neutrophil-induced injury. to test these hypotheses, we will expose cultured rat pulmonary alveolar epithelial cells. (and for comparison bovine pulmonary artery endothelial cells) to stimulated human neutrophils and/or exogenous oxygen metabolites. We will concurrently measure cytotoxicity, concentrations of ATP and related compounds, the activities of intracellular antioxidant systems, and specific membrane functions. The information will be used to construct a detailed pathway be which oxygen metabolites and stimulated neutrophils injure pulmonary alveolar epithelial cells. The information gained will provide an improved understanding of inflammatory damage to alveolar epithelium and should assist in developing treatments designed to reduce the lung injury in ARDS.
成人呼吸窘迫时发生的肺泡损伤

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Richard H Simon其他文献

327 HORMONAL REGULATION OF CHOLINE PHOSPHATE CYTIDYLTRANSFERASE (CYT) IN FETAL RAT ALVEOLAR TYPE II CELLS
  • DOI:
    10.1203/00006450-198504000-00357
  • 发表时间:
    1985-04-01
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    Rose M Viscardi;Richard H Simon;Paul Weinhold
  • 通讯作者:
    Paul Weinhold

Richard H Simon的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Richard H Simon', 18)}}的其他基金

Plasminogen activation system in pulmonary fibrosis
肺纤维化中的纤溶酶原激活系统
  • 批准号:
    6584877
  • 财政年份:
    2001
  • 资助金额:
    $ 13.76万
  • 项目类别:
GENE TRANSFER OF FIBRINOLYTIC AGENTS IN LUNG FIBROSIS
肺纤维化中纤溶剂的基因转移
  • 批准号:
    6410568
  • 财政年份:
    2000
  • 资助金额:
    $ 13.76万
  • 项目类别:
GENE TRANSFER OF FIBRINOLYTIC AGENTS IN LUNG FIBROSIS
肺纤维化中纤溶剂的基因转移
  • 批准号:
    6302445
  • 财政年份:
    1999
  • 资助金额:
    $ 13.76万
  • 项目类别:
GENE TRANSFER OF FIBRINOLYTIC AGENTS IN LUNG FIBROSIS
肺纤维化中纤溶剂的基因转移
  • 批准号:
    6110715
  • 财政年份:
    1998
  • 资助金额:
    $ 13.76万
  • 项目类别:
GENE TRANSFER OF FIBRINOLYTIC AGENTS IN LUNG FIBROSIS
肺纤维化中纤溶剂的基因转移
  • 批准号:
    6273196
  • 财政年份:
    1997
  • 资助金额:
    $ 13.76万
  • 项目类别:
GENE TRANSFER OF FIBRINOLYTIC AGENTS IN LUNG FIBROSIS
肺纤维化中纤溶剂的基因转移
  • 批准号:
    6242709
  • 财政年份:
    1996
  • 资助金额:
    $ 13.76万
  • 项目类别:
INFLAMMATORY INJURY OF LUNG ALVEOLAR EPITHELIAL CELLS
肺泡上皮细胞炎症损伤
  • 批准号:
    3356736
  • 财政年份:
    1988
  • 资助金额:
    $ 13.76万
  • 项目类别:
INFLAMMATORY INJURY OF LUNG ALVEOLAR EPITHELIAL CELLS
肺泡上皮细胞炎症损伤
  • 批准号:
    3356735
  • 财政年份:
    1988
  • 资助金额:
    $ 13.76万
  • 项目类别:
Plasminogen activation system in pulmonary fibrosis
肺纤维化中的纤溶酶原激活系统
  • 批准号:
    6998976
  • 财政年份:
  • 资助金额:
    $ 13.76万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了