INFLAMMATORY INJURY OF LUNG ALVEOLAR EPITHELIAL CELLS
肺泡上皮细胞炎症损伤
基本信息
- 批准号:3356734
- 负责人:
- 金额:$ 13.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1988
- 资助国家:美国
- 起止时间:1988-07-01 至 1991-06-30
- 项目状态:已结题
- 来源:
- 关键词:adult respiratory distress syndrome calcium transporting ATPase cell adhesion cell death cell membrane cellular pathology cow cytotoxicity detoxification electron microscopy fluorescent dye /probe high performance liquid chromatography human tissue hydrogen peroxide inflammation laboratory rat lung alveolus membrane permeability monoclonal antibody neutrophil nucleotide metabolism oxidizing agents oxidoreductase respiratory epithelium scanning electron microscopy singlet oxygen tissue /cell culture vascular endothelium
项目摘要
The alveolar injury that occurs in the adult respiratory distress
syndrome (ARDS) appears in many cases to be secondary to
activation of inflammatory processes, particularly those involving
neutrophils and/or oxygen metabolites. Injury of alveolar
epithelial cells has been found to be a prominent, early feature of
ARDS. Because the integrity of the alveolar epithelium is critical
in preventing fluid from accumulating within the alveolar
compartment, and because the alveolar epithelium has received
relatively little study compared to the vascular endothelium, this
proposal contains experiments designed to study the mechanisms
by which stimulated neutrophils and/or oxygen metabolites can
injure lung epithelial cells. The hypotheses are: that abberations
in ATP metabolism are intimately involved in the process of
injury; that the susceptibility of target cells to neutrophil-induced
injury is dependent upon their ability to detoxify oxidants; and
that epithelial cell membrane injury is a prominent, early feature
of neutrophil-induced injury. to test these hypotheses, we will
expose cultured rat pulmonary alveolar epithelial cells. (and for
comparison bovine pulmonary artery endothelial cells) to
stimulated human neutrophils and/or exogenous oxygen
metabolites. We will concurrently measure cytotoxicity,
concentrations of ATP and related compounds, the activities of
intracellular antioxidant systems, and specific membrane
functions. The information will be used to construct a detailed
pathway be which oxygen metabolites and stimulated neutrophils
injure pulmonary alveolar epithelial cells. The information gained
will provide an improved understanding of inflammatory damage
to alveolar epithelium and should assist in developing treatments
designed to reduce the lung injury in ARDS.
成人呼吸窘迫时发生的肺泡损伤
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Richard H Simon其他文献
327 HORMONAL REGULATION OF CHOLINE PHOSPHATE CYTIDYLTRANSFERASE (CYT) IN FETAL RAT ALVEOLAR TYPE II CELLS
- DOI:
10.1203/00006450-198504000-00357 - 发表时间:
1985-04-01 - 期刊:
- 影响因子:3.100
- 作者:
Rose M Viscardi;Richard H Simon;Paul Weinhold - 通讯作者:
Paul Weinhold
Richard H Simon的其他文献
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{{ truncateString('Richard H Simon', 18)}}的其他基金
Plasminogen activation system in pulmonary fibrosis
肺纤维化中的纤溶酶原激活系统
- 批准号:
6584877 - 财政年份:2001
- 资助金额:
$ 13.76万 - 项目类别:
GENE TRANSFER OF FIBRINOLYTIC AGENTS IN LUNG FIBROSIS
肺纤维化中纤溶剂的基因转移
- 批准号:
6410568 - 财政年份:2000
- 资助金额:
$ 13.76万 - 项目类别:
GENE TRANSFER OF FIBRINOLYTIC AGENTS IN LUNG FIBROSIS
肺纤维化中纤溶剂的基因转移
- 批准号:
6302445 - 财政年份:1999
- 资助金额:
$ 13.76万 - 项目类别:
GENE TRANSFER OF FIBRINOLYTIC AGENTS IN LUNG FIBROSIS
肺纤维化中纤溶剂的基因转移
- 批准号:
6110715 - 财政年份:1998
- 资助金额:
$ 13.76万 - 项目类别:
GENE TRANSFER OF FIBRINOLYTIC AGENTS IN LUNG FIBROSIS
肺纤维化中纤溶剂的基因转移
- 批准号:
6273196 - 财政年份:1997
- 资助金额:
$ 13.76万 - 项目类别:
GENE TRANSFER OF FIBRINOLYTIC AGENTS IN LUNG FIBROSIS
肺纤维化中纤溶剂的基因转移
- 批准号:
6242709 - 财政年份:1996
- 资助金额:
$ 13.76万 - 项目类别:
INFLAMMATORY INJURY OF LUNG ALVEOLAR EPITHELIAL CELLS
肺泡上皮细胞炎症损伤
- 批准号:
3356736 - 财政年份:1988
- 资助金额:
$ 13.76万 - 项目类别:
INFLAMMATORY INJURY OF LUNG ALVEOLAR EPITHELIAL CELLS
肺泡上皮细胞炎症损伤
- 批准号:
3356735 - 财政年份:1988
- 资助金额:
$ 13.76万 - 项目类别:
Plasminogen activation system in pulmonary fibrosis
肺纤维化中的纤溶酶原激活系统
- 批准号:
6998976 - 财政年份:
- 资助金额:
$ 13.76万 - 项目类别: