Molecular materials, sensors and circuits with nanometre resolution

具有纳米分辨率的分子材料、传感器和电路

• 批准号: EP/I016651/1
• 负责人: Eugen Stulz
• 金额: $ 25.73万
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FI016651%2F1
• 关键词: Molecular; materials; sensors; circuits; nanometre

We will use the Feasibility Account to explore how far and how fast new approaches to the DNA-programmed assembly of information-rich materials can be developed, leapfrogging incremental developments and establishing new research areas. We propose an adventurous combination of high-level DNA nanostructure design with state-of-the-art synthetic methodology to create designer materials that can be functionalized with nanometre precision and, through the reversibility of hybridisation and secondary structure formation, are responsive to external stimuli. We will synthesize chemically modified nucleosides bearing designer groups for electronics, biomolecule attachment and polymer-DNA hybrid material formation. Using the exquisite architectural control provided by DNA self-assembly, we will create nanostructures that incorporate these building blocks at programmable positions. We will focus on proof-of-concept experiments in areas covering molecular electronics, responsive materials and high-density sensor arrays.

我们将使用可行性帐户来探索开发dna编程组装信息丰富材料的新方法的距离和速度，跨越增量发展并建立新的研究领域。我们提出了一种将高水平DNA纳米结构设计与最先进的合成方法相结合的冒险方法，以创造出能够以纳米精度功能化的设计材料，并通过杂交和二级结构形成的可逆性，对外部刺激做出反应。我们将合成带有设计基团的化学修饰核苷，用于电子，生物分子连接和聚合物- dna杂化材料的形成。利用DNA自组装提供的精致结构控制，我们将创建在可编程位置包含这些构建块的纳米结构。我们将专注于涵盖分子电子学、响应材料和高密度传感器阵列等领域的概念验证实验。

项目成果

Increased duplex stabilization in porphyrin-LNA zipper arrays with structure dependent exciton coupling.

• DOI: 10.1039/c5ob01681a
• 发表时间: 2016-01-07
• 期刊: Organic & biomolecular chemistry
• 影响因子: 3.2
• 作者: Singleton DG;Hussain R;Siligardi G;Kumar P;Hrdlicka PJ;Berova N;Stulz E
• 通讯作者: Stulz E

Porphyrin-modified DNA as Construction Material in Supramolecular Chemistry and Nano-architectonics.

卟啉修饰的 DNA 作为超分子化学和纳米建筑材料的构建材料。

• DOI: 10.2533/chimia.2015.678
• 发表时间: 2015
• 期刊: Chimia
• 影响因子: 1.2
• 作者: Stulz E

Multistep DNA-Templated Reactions for the Synthesis of Functional Sequence Controlled Oligomers

用于合成功能性序列控制低聚物的多步 DNA 模板反应

• DOI: 10.1002/ange.201002721
• 发表时间: 2010
• 期刊: Angewandte Chemie
• 作者: McKee M