PHYSIOLOGY OF RECOVERY FROM INTERSTITIAL PULMONARY EDEMA

这些拟议调查的主要目的是 确定从间质性恢复的时间过程 肺水肿 几条通关路线将是 量化，但主要侧重于新发现的 纵隔清除途径。 我们的具体目标是：1） 确定高或低浓度间质性水肿液体 从肺中清除低浓度的蛋白质，以测试 假设高蛋白质渗透压水肿液， 限制血液重吸收，将被清除得比 低蛋白渗透压水肿; 2）量化途径 各种形式的间质液体清除 肺水肿，以检验纵隔 途径是间质性水肿清除的主要途径; 3)为了量化支气管血管周围间质的贡献， 水肿肺淋巴液流，以检验假设，有 通过淋巴系统的清除率很低。 我们获得的数据 将阐明，定量，肺的各种途径的作用， 间质液和蛋白质流动。 这将为科学家提供一个 更好地了解各种形式的总病理生理学 肺水肿，并将给医生一个更好的 从自然历史的角度来理解 从水肿中恢复，这将使他们能够设计新的 能提高清除率的治疗方法 将进行实验 在三个物种（绵羊，山羊，兔子）;每一个特定的必要 为特定问题提供最佳解决方案，以及 测试结果的一般种间适用性。

The main objective of these proposed investigations is to determine the time course of recovery from interstitial pulmonary edema. The several routes of clearance will be quantified but the main emphasize will on the newly-discovered mediastinal clearance pathway. Our specific aims are: 1) to determine the rate at which interstitial edema liquid of high or low protein concentration is cleared from the lung, to test the hypothesis that edema liquid of high protein osmotic pressure, by limiting blood reabsorption, will be cleared less quickly than will edema of low protein osmotic pressure; 2) to quantify the routes of interstitial liquid clearance in various forms of interstitial pulmonary edema, to test the hypothesis that the mediastinal pathway is the principal route of interstitial edema clearance; and 3) to quantify the contribution of peribronchovascular interstitial edema to lung lymph flow, to test the hypothesis that there is little clearance via the lymphatic system. The data we obtain will clarify, quantitatively, the role of various pathways of lung interstitial liquid and protein flow. This will give scientists a better understanding of the total pathophysiology of various forms of pulmonary edema and will give physicians a better understanding of what to expect in terms of the natural history of recovery from edema, which will enable them to design new treatments that will enhance clearance. Experiments will be done in three species (sheep, goat, rabbit); each specifically necessary to provide the best solution to a particular problem, as well as to test the general interspecies applicability of the results.