Molecular mechanisms causing relapse

导致复发的分子机制

• 批准号: DE170100509
• 负责人: Dr Asheeta Prasad
• 金额: $ 27.14万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE170100509
• 关键词: Molecular; mechanisms; causing; relapse

This project aims to identify the neural connectivity and molecular profile of ventral pallidal neurons in the brain that control drug and alcohol addiction, relapsing disorders where users lose the ability to inhibit drug seeking behaviour. This project integrates neurobiological and psychological attributes of relapse. The anticipated outcomes provide insights about molecular mechanisms causing relapse, and expand knowledge of brain mechanisms that contribute to relapsing disorders such as drug addiction and obesity. The findings from this project could be used to reduce relapse, and hence reduce the burden of alcohol related problems on health, the community and the Australian economy.

该项目旨在确定大脑中腹侧苍白球神经元的神经连接和分子特征，这些神经元控制药物和酒精成瘾，复发性疾病，其中用户失去抑制药物寻求行为的能力。该项目整合了复发的神经生物学和心理学属性。预期的结果提供了有关导致复发的分子机制的见解，并扩大了对药物成瘾和肥胖等复发性疾病的大脑机制的了解。该项目的研究结果可用于减少复发，从而减轻酒精相关问题对健康，社区和澳大利亚经济的负担。