KINETICS OF GAS EXCHANGE IN THE PULMONARY CIRCULATION

描述(摘自申请者摘要)：肺气率 交换受许多因素的影响，但这两个主要过程 似乎限制了O2和C02交换动力学的持续时间 毛细血管通过时间和毛细血管内反应速度 呼吸性气体。因此，申请人提议研究该变种。 在肺血管系统不同节段的传输时间 以及在完整的肺循环中的气体交换率。这个 气体交换的动力学将在隔离的、灌流的肺中确定。 容积仪中包含的制剂。肺部会被灌流 通过液压泵来缓冲，它还可以从 以相同的速率测量体积，以防止任何净体积变化。A 2.0毫升 将反应物团注到灌流系统中。后续 气体交换产生压力瞬变，这与 相应体积的交换气体。在了解了集中度的情况下 团注的轮廓，观察到的惰性气体的交换 在团剂中溶解，以及注射后的氧气交换速度 一团连二亚硫酸钠，申请人将决定 动脉段和毛细血管段的通过时间分布 肺循环。注射红细胞悬浮液将 指示毛细管气体交换的速率。

DESCRIPTION (adapted from applicant's abstract): The rate of pulmonary gas exchange is affected by many factors but the two principal processes which appear to limit the kinetics of 02 and C02 exchange are the duration of capillary transit time and the rates of intracapillary reactions of the respiratory gases. Therefore the applicant proposes to study the variation in transit times throughout different segments of the pulmonary vasculature and the rate of gas exchange in the intact circulation of the lung. The kinetics of gas exchange would be determined in an isolated, perfused lung preparation contained within a plethysmograph. The lungs would be perfused with buffer by a hydraulic pump which also removes water from the plethysmograph at the same rate to prevent any net volume change. A 2.0 ml bolus of reactant would be injected into the perfusion system. Subsequent gas exchange produces a pressure transient which is related to the corresponding volume of exchanged gas. With knowledge of the concentration profile of a bolus injection, the observed exchange of an inert gas dissolved in a bolus, and the rate of oxygen exchange following injection of a bolus of sodium dithionite, the applicant would determine the distribution of transit times in the arterial and capillary segments of the pulmonary circulation. Injection of suspensions of erythrocytes would indicate the rate of capillary gas exchange.