Seeing deeply inside the body with the world's smallest microscope

用世界上最小的显微镜深入观察身体内部

• 批准号: DE170100241
• 负责人: Dr Martin Ploschner
• 金额: $ 26.03万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-03-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE170100241
• 关键词: Seeing; deeply; inside; body; world

This project aims to develop the world's smallest in vivo microscope that can image the interior of living organisms at a subcellular resolution in a minimally invasive way. The project will shrink an entire microscope to the size of an optical fibre – as thin as a single strand of hair – and image deep regions of the central nervous system. This is expected to improve diagnostic tools and the knowledge of degenerative brain diseases, including Alzheimer's disease and amyotrophic lateral sclerosis. This project aims to completely transform the landscape of biomedical research and industry, with expected discoveries revolutionising the diagnosis and treatment of brain conditions.

该项目旨在开发世界上最小的活体显微镜，以最小的侵入方式以亚细胞分辨率对活生物体内部进行成像。该项目将把整个显微镜缩小到一根光纤的大小--细如一根头发丝--并对中枢神经系统的深层区域进行成像。这有望改善诊断工具和退行性脑疾病的知识，包括阿尔茨海默病和肌萎缩侧索硬化症。该项目旨在彻底改变生物医学研究和产业的格局，预期的发现将彻底改变大脑疾病的诊断和治疗。