GENETIC LINKAGE STUDIES IN AFFECTIVE DISORDERS

利用分子遗传学技术， 这项研究的目的是将X连锁双相情感障碍患者的疾病基因 情感疾病和检测其他主要基因在 疾病的传播。 这些目标将在1. 基因定位和相关DNA技术; 2. 导电连杆 在分离双相情感障碍的合适家系中使用DNA标记的研究 和相关的情感障碍。 这项研究还将旨在 在临床测量中表征关联与非关联病例， 试图识别和定义疾病的同质子集 并比较不同的人口和种族群体， 遗传差异。长期目标将包括克隆 缺陷基因;结构测定;寻找 及其生物制品;以及基因-环境评价 互动 以色列是数据收集网站。 主要有六个原因 对于这个选择：1。X染色体连锁的家系已经被 鉴定 2.大型多代谱系的可用性 有多个受影响的病例可以随时进行研究。 3.酗酒和吸毒的比例很低， 精神病诊断。 4.有机会比较不同的 人口和文化。 5. 以往的成功合作和 需要扩展的有趣发现。 6.相对较低 人类研究的成本。 以色列，也许是独一无二的， 要求. 一个独特的人口的可用性，加上最近的 方法学的进步，如分子遗传技术， 有系统地获取家庭数据的方法， 访谈，提高可靠性的精确诊断标准; 以及一系列的遗传模型， 情感疾病的遗传机制 而这 反过来，可能对病因学，疾病分类学， 病理生理学，以及可能的预防和治疗这些 紊乱

Using molecular genetic techniques, the chief objectives of this proposal are to home in on the disease gene in X-linked bipolar affective illness and to detect other major genes in the transmission of the disorder. These goals will be attained by 1. gene mapping and related DNA techniques; and 2. conducting linkage studies with DNA markers in suitable pedigrees segregating bipolar and related affective disorders. The study will also aim to characterize linked vs. unlinked cases on clinical measures in an attempt to identify and define homogeneous subsets of the disorder and to compare different populations and ethnic groups for possible genetic differences. Long-term goals will include cloning of the defective genes; determination of their structure; searching for their biological products; and assessment o( gene-environment interaction. Israel is the data collection site. There are six main reasons for this choice: 1. X-linked pedigrees have already been identified. 2. Availability of large multigenerational pedigrees with multiple affected cases that are readily accessible for study. 3. Low rates of alcoholism and drug use, conditions that confound the psychiatric diagnosis. 4. An opportunity to compare different populations and culture. 5. Previous successful collaboration and intriguing findings that require extension. 6. The relatively low cost of human research. Israel, probably uniquely, meets all these requirements. The availability of a unique population, coupled with recent methodological advances such as molecule genetic techniques, approaches to systematically obtaining family data, structured interviews, precise diagnostic criteria with improved reliability; and a range of genetic models, holds much promise for unraveling the genetic mechanisms that underlie affective illness. This, in turn, could have major implications for the etiology, nosology, pathophysiology and, possibly, prevention and treatment of these disorders.