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ADOLESCENT DEPRESSION: NEUROPHARMACOLOGY AND BIOLOGY

ADOLESCENT DEPRESSION: NEUROPHARMACOLOGY AND BIOLOGY
青少年抑郁症：神经药理学和生物学
批准号：
3380836
负责人：
DENNIS P CANTWELL
金额：
$14.86万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1987
资助国家：
美国
项目状态：
已结题
起止时间：
1987-02-01 至 1990-01-31
来源：
https://reporter.nih.gov/project-details/3380836
关键词：
3 methoxy 4 hydroxyphenylethyleneglycol adolescence (12-20) alpha adrenergic receptor antidepressants beta adrenergic receptor catecholamines cortisol dopamine drug withdrawal epinephrine high performance liquid chromatography homovanillate human subject human therapy evaluation mental disorder chemotherapy neuropharmacology neurotransmitters norepinephrine normetanephrine nortriptyline placebos psychophysiology urinalysis

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中文摘要
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英文摘要
This is a request for four years of support to study 80 adolescent inpatients with Major Depressive Disorder (MDD). A random assignment, double-blind, placebo-controlled trial of Nortriptyline (NT) will be carried out over an 8-week period followed by a placebo withdrawal phase. Correlates of response to and relapse from NT treatment will be studied. Correlates to be studied include: Familial aggregation of psychopathology, neuroendocrine measures, monoamine measures, and associated clinical (non-depressive) symptoms. Correlations between different types of biological measures, and between biological measures and clinical and family measures will also be investigated.
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ADOLESCENT DEPRESSION: NEUROPHARMACOLOGY AND BIOLOGY