ADOLESCENT DEPRESSION: NEUROPHARMACOLOGY AND BIOLOGY

青少年抑郁症：神经药理学和生物学

• 批准号: 3380836
• 负责人: DENNIS P CANTWELL
• 金额: $ 14.86万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-02-01 至 1990-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3380836
• 关键词: 3 methoxy 4 hydroxyphenylethyleneglycol; adolescence (12-20); alpha adrenergic receptor; antidepressants; beta adrenergic receptor; catecholamines; cortisol; dopamine; drug withdrawal; epinephrine; high performance liquid chromatography; homovanillate; human subject; human therapy evaluation; mental disorder chemotherapy; neuropharmacology; neurotransmitters; norepinephrine; normetanephrine; nortriptyline; placebos; psychophysiology; urinalysis

This is a request for four years of support to study 80 adolescent inpatients with Major Depressive Disorder (MDD). A random assignment, double-blind, placebo-controlled trial of Nortriptyline (NT) will be carried out over an 8-week period followed by a placebo withdrawal phase. Correlates of response to and relapse from NT treatment will be studied. Correlates to be studied include: Familial aggregation of psychopathology, neuroendocrine measures, monoamine measures, and associated clinical (non-depressive) symptoms. Correlations between different types of biological measures, and between biological measures and clinical and family measures will also be investigated.

这是一份为期四年的支持请求，研究80名青少年 重度抑郁症（MDD）患者。 随机分配， 将进行一项去甲替林（NT）的双盲、安慰剂对照试验， 在8周的时间内进行，然后是安慰剂戒断期。 将研究NT治疗的反应和复发的相关性。 有待研究的相关因素包括：精神病理学的家族聚集， 神经内分泌测量、单胺测量和相关临床 （非抑郁）症状。 不同类型之间的关系 生物措施，以及生物措施与临床和 还将调查家庭措施。