STATE DEPENDENT CONTROL OF SOMATIC REFLEX ACTIVITY

躯体反射活动的状态依赖性控制

• 批准号: 3394128
• 负责人: MICHAEL H CHASE
• 金额: $ 13.7万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-08-01 至 1987-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3394128
• 关键词: adrenergic agents; antiadrenergic agents; brain electrical activity; electrophysiology; experimental brain lesion; medulla oblongata; membrane potentials; microelectrodes; microinjections; motor neurons; neural information processing; neural inhibition; neural initiation; neuropharmacology; neuropsychology; neurotransmitters; nontherapeutic iontophoresis; pons; psychobiology; reticular formation; sensorimotor system; sleep; somatic reflex; synapses; wakefulness

The research described in this application is designed to examine the neuronal circuitry and neurotransmitters which are responsible for the state-dependent modulation of trigeminal motoneuron membrane potential activity. Interdisciplinary electrophysiological and iontophoretic studies are proposed, each of which relates to and complements the others. These studies, which are organized within the framework of an examination of the paradoxical phenomenon of "reticular response-reversal", entail a determination of the state-dependent activity of and interrelationships between the nucleus pontis oralis, the nucleus reticularis gigantocellularis and the trigeminal motor nucleus. The proposed studies should (1) clarify a number of the specific pathways and synaptic processes that are involved in the modulation of brainstem motoneuron membrane potential activity during sleep and wakefulness, (2) generate a normative fund of information relating to the neurotransmitters underlying various patterns of postsynaptic inhibition during active sleep, and (3) provide a new experimental paradigm for studying the neurotransmitters mediating behavioral activities from an intracellular perspective utilizing iontophoretic techniques in the chronic, unanesthetized, normally respiring animals.

本申请中描述的研究旨在检查 神经元回路和神经递质负责 三叉神经运动神经元膜电位的状态依赖性调节 活动 跨学科电生理和离子电渗研究 每一项都与其他各项相关并相互补充。 这些 研究，这些研究是在审查 “网状反应逆转”的矛盾现象， 确定依赖于状态的活动和相互关系 脑桥口侧核网状核 三叉神经运动核。 拟议的研究应（1）澄清一些具体途径 以及参与脑干调节的突触过程 运动神经元在睡眠和觉醒时的膜电位活动，（2） 产生与神经递质相关的信息的规范性基金 在活跃睡眠期间潜在的各种突触后抑制模式， （3）提供了一个新的研究实验范式 神经递质介导的行为活动，从细胞内 在慢性， 未麻醉正常呼吸的动物