STATE DEPENDENT CONTROL OF SOMATIC REFLEX ACTIVITY

此应用程序中描述的研究旨在检查 神经回路和神经递质负责 三叉神经运动神经元膜电位的状态依赖性调制 活动。跨学科的电生理学和离子导入研究 每一项都是相互关联和相辅相成的。这些 研究，这些研究是在对 “网状反应-反转”的悖论现象，需要一个 与状态相关的活性的确定及其相互关系 在脑桥口侧核、网状核之间 巨细胞和三叉神经运动核。 拟议的研究应(1)澄清一些具体的途径 和参与脑干调制的突触过程 睡眠和清醒状态下运动神经元的膜电位活动(2) 建立与神经递质有关的标准化信息基金 在活跃睡眠期间突触后抑制的各种模式下， (3)提供了一种新的实验范式。 神经递质介导细胞内的行为活动 利用离子导入技术治疗慢性阻塞性肺疾病的前景 未麻醉的、正常呼吸的动物。

The research described in this application is designed to examine the neuronal circuitry and neurotransmitters which are responsible for the state-dependent modulation of trigeminal motoneuron membrane potential activity. Interdisciplinary electrophysiological and iontophoretic studies are proposed, each of which relates to and complements the others. These studies, which are organized within the framework of an examination of the paradoxical phenomenon of "reticular response-reversal", entail a determination of the state-dependent activity of and interrelationships between the nucleus pontis oralis, the nucleus reticularis gigantocellularis and the trigeminal motor nucleus. The proposed studies should (1) clarify a number of the specific pathways and synaptic processes that are involved in the modulation of brainstem motoneuron membrane potential activity during sleep and wakefulness, (2) generate a normative fund of information relating to the neurotransmitters underlying various patterns of postsynaptic inhibition during active sleep, and (3) provide a new experimental paradigm for studying the neurotransmitters mediating behavioral activities from an intracellular perspective utilizing iontophoretic techniques in the chronic, unanesthetized, normally respiring animals.