ELECTROPHYSIOLOGY OF LIMBIC NEURONS

电子记录将由不同来源的单个神经元进行 海马区的部分结构(阿蒙角、齿状回、 下丘、下丘前、下丘后、下丘旁、内侧和 自由活动大鼠的外侧内嗅皮层和周围皮质) 以电视-计算机为基础的系统进行定量分析。在任务中 其中一些区域的神经元是已知的 当老鼠在特定位置或当老鼠的头 指向特定的方向，或位置和 方向，即用信号通知某些类型的 导航。从已知的情况来看， 导航信息可以部分勾画出来。通过录制 从更多的地区来看，这种流动和转变应该会变得 更清楚了。将引入一项新的任务，在其中老鼠将在 两个不同的环境。这项任务的目的是特别测试 头部跨环境定向射击的控制。差不多了 人们对导航的神经机制一无所知。这个 在痴呆症中，导航能力经常丧失，这是一种特殊的 严重的赤字，因为人们迷失了方向。导航是复杂的非 语言认知，以及流动的细胞分析问题和 在这一认知过程中表征的转换似乎 是可以解决的。

Eletrical recordings will be made from single neurons from different parts of the hippocampal formation (Ammon's horn, dentate gyrus, subiculum, presubiculum, postsubiculum, parasubiculum, medial and lateral entorhinal cortex and perirhinal cortex) in freely moving rats quantitatively analyzed with a TV-computer based system. In the tasks whichl will be used, neurons from some of these regions are known to fire when the rat is at a specific location or when the rat's head is pointing a specific direction, or some combination of location and direction, i.e., to signal information necessary for some kinds of navigation. From what is known already, the flow and transformation of navigational information can be partially sketched out. By recording from more regions, this flow and transformation should become much clearer. A new task will be introduced in which rats will move between two different environments. This task is designed to especially test the control of head directional firing across environments. Almost nothing is known about the neuronal mechanisms of navigation. The ability to navigate is often lost in dementia, and is an especially serious deficit because the people get lost. Navigation is complex non verbal cognition, and the problem of cellular analysis of flow and transformation of representations in this cognitive process seems solvable.