STRUCTURAL ORGANIZATION OF THE MUSCLE SPINDLE

肌梭的结构组织

• 批准号: 3399195
• 负责人: JAN KUCERA
• 金额: $ 10.78万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-01-01 至 1989-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3399195
• 关键词: afferent nerve; axon; efferent nerve; electron microscopy; histology; human tissue; innervation; microscopy; motor neurons; myofibrils; neural information processing; neuroanatomy; stretch receptors

This application proposes structural and functional analyses of the internal organization of the mammalian muscle spindle. Neural and muscular features of spindles will be compared: among cat, monkey and man; among functionally different muscles of monkey; and among single isolated human spindles from which afferent responses have been elicited by stimulation of known fusimotor axons. The proposed research addresses: a) whether efferent and afferent features of the human spindle are similar to those of spindles in cat or monkey; b) whether particular, anatomy-dependent motor tasks (flexion vs. extension) necessitate a particular internal organization of spindle; c) whether 'mixed' afferent fusimotor actions have a neural or muscular origin; d) the nature of factors that determine the neural organization of human spindle; e) how the anatomical features of innervation of individual intrafusal fibers and variability in structure along the length of fibers, translate into functional attributes of afferents in single, isolated human spindles. Motor and sensory innervation of spindles are reconstructed by light microscopy of serial transverse sections of plastic-embedded material. Ultrastructure of intrafusal fibers is analyzed qualitatively and quantitatively from electron micrographs. Structural properties of spindles are correlated directly with afferent responses in single, isolated organs in vitro. The study represents the first comparative analysis of the nerve supply of spindles in different muscles and in different species of mammal, and the first comprehensive anatomical/physiological study of the human muscle spindle. The work is essential for clarifying the role of efferent and afferent nerve supplies of the mammalian spindle in controlling movement and posture.

该应用提出了对结构和功能分析的 哺乳动物肌肉主轴的内部组织。 神经和肌肉 将比较主轴的特征：在猫，猴子和人中；之中 猴子的功能不同；在一个孤立的人 通过刺激引起传入响应的纺锤体 已知的融合轴突。 拟议的研究解决了：a）是否有传出和传入功能 人体主轴类似于猫或猴子中的纺锤体。 b） 是否特别，依赖解剖学的运动任务（屈曲与扩展） 需要特定的内部主轴组织； c）是否 “混合”传入融合动作具有神经或肌肉的起源。 d） 决定人主轴神经组织的因素的性质； e）单个自节内神经支配的解剖学特征如何 沿纤维长度的纤维和结构变异性，翻译 在单个，孤立的人纺锤体中的传入的功能属性。 电动机和纺锤的感觉神经由光重构 塑料包裹材料的连续横向切片的显微镜。 定性分析恒星纤维的超微结构 从电子显微照片定量。 结构特性 纺锤体与单个中的传入响应直接相关， 体外孤立的器官。 该研究代表了神经供应的首次比较分析 不同肌肉和不同种类的哺乳动物中的纺锤体， 人类肌肉的首个全面的解剖学/生理研究 主轴。 这项工作对于阐明传出的作用至关重要 哺乳动物纺锤体的传入神经供应控制运动 和姿势。