Characterisation of bone and bone marrow resident tissue macrophages

骨和骨髓驻留组织巨噬细胞的表征

• 批准号: FT160100314
• 负责人: Prof Allison Pettit
• 金额: $ 48.82万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT160100314
• 关键词: Characterisation; bone; marrow; resident; tissue

This project aims to elucidate the identities of tissue macrophages involved in bone and blood system (bone marrow) homeostasis and function, and the molecular signatures underpinning their functional specialisation. It will then investigate whether decline in the function of these specialised macrophages occurs during skeletal and blood system ageing. Both skeletal and blood system decline contribute to age-associated loss of productivity, and paralleled decline in the resident macrophages in these organs may be a common ageing mechanism. Demonstration that altered macrophage biology unpins decline in blood and bone may prolong peak health and increase productivity in the ageing population.

该项目旨在阐明参与骨骼和血液系统（骨髓）稳态和功能的组织巨噬细胞的身份，以及支撑其功能专业化的分子特征。然后，它将研究这些特殊巨噬细胞的功能是否会在骨骼和血液系统衰老过程中发生下降。骨骼和血液系统的衰退都会导致与年龄相关的生产力损失，而这些器官中常驻巨噬细胞的平行衰退可能是一种常见的衰老机制。巨噬细胞生物学的改变可以缓解血液和骨骼的衰退，这可能会延长老年人的最佳健康状态并提高生产力。