STUDIES OF THE NEURAL BRAINSTEM AUDITORY RESPONSES

可以从头皮记录的声音诱发电位是 在各种疾病的临床诊断中变得越来越重要， 影响中枢神经系统的疾病，如肿瘤和多种 硬化症 特别是，所谓的短延迟组件 脑干听觉诱发电位（brainstem auditory evoked potentials，BSEP）已被证明非常有用 做出这样的诊断。 该方法在精确定位病变部位中的应用 然而，测试受到不确定性的阻碍， 反应的各个组成部分的神经发生器。 目的 本研究的目的是为了更好地了解 远场电事件，可以从头皮记录在 第一个10毫秒后的瞬态声音的发作，并确定 这些电位的神经发生器。 这将通过 在神经外科手术期间和在神经外科手术中的颅内记录中， 动物实验。 不同脑核团的选择性记录将 在人类和动物实验中都可以实现。 的可能性 某些神经束或神经核是某些部分的发生器， 头皮记录的BSEP将通过确定 反应和发生器的解剖延伸。 实验将 在狒狒中进行，其中脉动压力对不同的 部分听觉神经系统将被研究， 气球。 反应对不同类型刺激的依赖性 将进行探索，以找到不同类型的最佳刺激， 问题研究 更好地了解这些潜力的来源， 它们对刺激参数的依赖性将增加 这种测试方法，并扩大其在疾病的鉴别诊断中的应用 影响听觉神经系统

The sound evoked potentials that can be recorded from the scalp are becoming of increasing importance in the clinical diagnosis of various diseases affecting the central nervous system such as tumors and multiple sclerosis. In particular, the so-called short latency components (brainstem auditory evoked potentials, BSEP) have proven to be very useful in making such diagnoses. The use of this method in precise site-of-lesion testing is, however, hampered by uncertainty as to the exact location of the neural generators of the various components of the response. The aim of this study is to obtain a better understainding of the sources of the farfield electrical events that can be recorded from the scalp during the first 10 msec after the onset of a transient sound and to identify the neural generators of these potentials. This will be done through intracranial recordings in humans during neurosurgical operations and in animal experiments. Selective recordings from different brain nuclei will be made in both the human and animal experiments. The likelihood of a certain nerve tract or nucleus being the generator of certain parts of the scalp-recorded BSEP will be studied by determining the amplitude of the response and the anatomical extension of the generator. Experiments will be performed in baboons where the effect of pulsatile pressure on different parts of the auditory nervous system will be studied using implantable balloons. The dependence of the response on different types of stimuli will be explored in order to find optimal stimuli for different types of studies. A better understanding of the origin of these potentials and their dependence on stimulus parameters will increase the cllnical value of this test method and broaden its use in differential diagnosis of disorders afflicting the auditory nervous system.