NEUROPHARMACOLOGY OF NEUROPEPTIDE Y & FEEDING BEHAVIORS

神经肽 Y 的神经药理学

• 批准号: 3404705
• 负责人: John E Morley
• 金额: $ 14.09万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-02-01 至 1988-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3404705
• 关键词: adrenalectomy; alpha adrenergic agent; appetite regulatory center; brain mapping; centrally acting drug; drug tolerance; eating; experimental brain lesion; hypothalamus; norepinephrine; nutrition related tag; vagotomy; water drinking behavior

Neuropeptide Y (NPY) is a newly discovered brain peptide. It has recently been shown to be a most potent orexigenic agent after central administration. It is the specific aim of this proposal to investigate the mechanism(s) by which NPY produces its stimulatory effects on consummatory behaviors and the site(s) within the central nervous system where it produces its effects. The localization of the sites of action of NPY will be accomplished by the utilization of two techniques viz. local injections and brain lesioning techniques. In the second part of this grant we will explore (i) whether the drinking accompanying NPY-induced eating is obligatory drinking secondary to the eating, (ii) whether tolerance develops to repeated injections of NPY and (iii) the relationship of NPY to norepinephrine-induced feeding. This proposal should provide new information on the role of a new central stimulator of feeding. This basic science information should prove useful in developing new approaches to the therapy of human feeding disorders. Our recent observation that NPY can reverse the anorexia of aged rats, suggests that further studies into NPY may give clues into the pathogenesis of the anorexia of aging.

神经肽Y（NPY）是一种新发现的脑肽。 最近有 已被证明是继中枢神经系统之后最有效的食欲促进剂 行政。 本提案的具体目的是调查 NPY 对完成性产生刺激作用的机制 行为和中枢神经系统内的部位 产生其效果。 NPY 作用位点的本地化将 通过使用两种技术来完成，即。局部注射 和脑损伤技术。 在这笔赠款的第二部分中，我们将 探讨 (i) 伴随 NPY 诱导饮食的饮酒是否是 继饮食之后必须饮酒，（ii）是否耐受 发展到重复注射 NPY 以及 (iii) NPY 与 去甲肾上腺素诱导的喂养。 该提案应提供新的 有关新的进食中枢刺激器作用的信息。 这个基本的 科学信息应该被证明对于开发新的方法是有用的 人类进食障碍的治疗。 我们最近观察到 NPY 可以 逆转老年大鼠的厌食症，表明对 NPY 的进一步研究 可能为衰老厌食症的发病机制提供线索。