NEUROPHARMACOLOGY OF NEUROPEPTIDE Y & FEEDING BEHAVIORS

神经肽Y（neuropeptide Y，NPY）是一种新发现的脑肽。 它最近 被证明是一个最有效的食欲剂后，中央 局 本提案的具体目的是调查 NPY产生其刺激作用的机制 行为和中枢神经系统内的部位， 产生其影响。 NPY作用位点的定位将 通过使用两种技术来完成，即局部注射 和脑损伤技术。 在第二部分，我们将 （一）饮酒是否伴随着NPY诱导的进食， （二）饮食中必须饮酒，（二）是否耐受 发展到重复注射NPY和（iii）NPY与 去甲肾上腺素诱导的进食。 该提案应提供新的 关于一种新的中枢进食刺激器的作用的信息。 这一基本 科学信息应证明有助于开发新的方法， 人类进食障碍的治疗。 我们最近观察到NPY可以 逆转老年大鼠的厌食症，表明对NPY的进一步研究 可能为老年厌食症的发病机制提供线索。

Neuropeptide Y (NPY) is a newly discovered brain peptide. It has recently been shown to be a most potent orexigenic agent after central administration. It is the specific aim of this proposal to investigate the mechanism(s) by which NPY produces its stimulatory effects on consummatory behaviors and the site(s) within the central nervous system where it produces its effects. The localization of the sites of action of NPY will be accomplished by the utilization of two techniques viz. local injections and brain lesioning techniques. In the second part of this grant we will explore (i) whether the drinking accompanying NPY-induced eating is obligatory drinking secondary to the eating, (ii) whether tolerance develops to repeated injections of NPY and (iii) the relationship of NPY to norepinephrine-induced feeding. This proposal should provide new information on the role of a new central stimulator of feeding. This basic science information should prove useful in developing new approaches to the therapy of human feeding disorders. Our recent observation that NPY can reverse the anorexia of aged rats, suggests that further studies into NPY may give clues into the pathogenesis of the anorexia of aging.