NEUROPHARMACOLOGY OF NEUROPEPTIDE Y & FEEDING BEHAVIORS

神经肽Y(NPY)是一种新发现的脑多肽。最近是这样的 已被证明是仅次于中枢神经的最有效的增食剂 行政管理。这项建议的具体目的是调查 神经肽Y刺激消费的机制(S) 行为与中枢神经系统内的部位(S) 产生它的效果。NPY Will作用部位的本土化 通过使用两种技术来实现，即。局部注射 以及脑部损伤技术。在这笔赠款的第二部分，我们将 探讨(I)饮酒是否伴随NPY诱导的进食 强制性饮酒次于进食，(Ii)是否耐受 发展到重复注射NPY和(III)NPY与 去甲肾上腺素诱导的进食。这项建议应该提供新的 关于新的喂养中枢刺激物的作用的信息。这是基本的 科学信息应该被证明是有用的，以开发新的方法 人类进食障碍的治疗。我们最近观察到NPY可以 逆转老年大鼠厌食症，提示对NPY的进一步研究 可能为老年性厌食症的发病机制提供线索。

Neuropeptide Y (NPY) is a newly discovered brain peptide. It has recently been shown to be a most potent orexigenic agent after central administration. It is the specific aim of this proposal to investigate the mechanism(s) by which NPY produces its stimulatory effects on consummatory behaviors and the site(s) within the central nervous system where it produces its effects. The localization of the sites of action of NPY will be accomplished by the utilization of two techniques viz. local injections and brain lesioning techniques. In the second part of this grant we will explore (i) whether the drinking accompanying NPY-induced eating is obligatory drinking secondary to the eating, (ii) whether tolerance develops to repeated injections of NPY and (iii) the relationship of NPY to norepinephrine-induced feeding. This proposal should provide new information on the role of a new central stimulator of feeding. This basic science information should prove useful in developing new approaches to the therapy of human feeding disorders. Our recent observation that NPY can reverse the anorexia of aged rats, suggests that further studies into NPY may give clues into the pathogenesis of the anorexia of aging.