BIOLOGICAL MARKERS OF ALCOHOL CONSUMPTION AMONG WOMEN

申请人摘要：健康和社会护理专业人员试图 适当地应对不断增加的与酒精有关的 妇女问题受到两个重要因素的阻碍：1） 众所周知，基于自我报告的酒精消费估计 不准确，2）研究生物标记物的可能用途， 纠正自我报告的不准确之处并不广泛。 我会 尝试确定γ-谷氨酰转肽酶（GGTP）的水平， 尿多萜醇的水平，或定量 碳水化合物缺乏转铁蛋白（CDT）可用作 长期过量饮酒或监测对酒精的依从性 禁欲方案，特别是在育龄妇女中。 受试者（约30名女性酗酒者和30名女性对照）将 参加关于饮酒行为的面试，完成 密歇根州酒精中毒筛查测试（MAST），同意采访一个 重要的其他人来证实，并提供血液和尿液 用于随后分析GGTP活性，尿多萜醇水平， CDT金额 将进行相关分析以检查 自我报告与生化水平之间的相关性。 此外， 将GGTP、尿长激素和CDT与既定标准进行比较 对于不喝酒的人和已知的范围为重度消费者的酒精。

APPLICANT'S ABSTRACT: Attempts of health and social care professionals to respond appropriately to the ever-increasing numbers of alcohol-related problems among women are handicapped by two important factors: 1) estimates of alcohol consumption based on self-report are notoriously inaccurate and 2) research into the possible use of biological markers to remedy the self-report inaccuracies has hardly been extensive. I will attempt to determine if levels of gamma-glutamyl transpeptidase (GGTP), levels of urinary dolichols, or the quantification of carbohydrate-deficient transferrin (CDT) can be used as indicators of chronic excessive alcohol consumption or to monitor compliance with alcohol abstinence programs, particularly among women of child-bearing age. Subjects (approximately 30 female alcoholics and 30 female controls) will participate in an interview regarding drinking behavior, complete the Michigan Alcoholism Screening Test (MAST), consent to the interview of a significant other for corroboration, and provide both a blood and urine sample for subsequent analysis for GGTP activity, urinary dolichol levels, and CDT amount. A correlational analysis will be run to examine the correlation between self-report and biochemical levels. As well, levels of GGTP, urinary dolichols, and CDT will be compared to the established norms for nondrinkers and the known range for heavy consumers of alcohol.