BIOLOGICAL MARKERS OF ALCOHOL CONSUMPTION AMONG WOMEN

申请者摘要：卫生和社会护理专业人员尝试 对不断增加的与酒精有关的人数做出适当的反应 妇女的问题受到两个重要因素的阻碍：1) 基于自我报告的酒精消费量估计是出了名的 不准确和2)研究使用生物标记的可能性 纠正自我报告的不准确几乎没有广泛的内容。这就做 试图确定γ-谷氨酰转肽酶(GGTP)水平， 尿多糖醇水平，或量化的 糖类缺乏性转铁蛋白(CDT)可作为 长期过量饮酒或监测饮酒依从性 禁欲方案，特别是在育龄妇女中。 受试者(大约30名女性酗酒者和30名女性对照)将 参加有关饮酒行为的访谈，完成 密歇根州酒精中毒筛查试验(MAST)，同意采访一名 重要的其他佐证，并提供血液和尿液 用于后续分析的样本GGTP活性，尿二醇水平， 和CDT数量。将运行相关分析来检查 自我报告与生化水平的相关性。同样，水平的 GGTP、尿多糖醇和CDT将与已建立的正常值进行比较 对于不喝酒的人，以及已知的酒精重度消费者的范围。

APPLICANT'S ABSTRACT: Attempts of health and social care professionals to respond appropriately to the ever-increasing numbers of alcohol-related problems among women are handicapped by two important factors: 1) estimates of alcohol consumption based on self-report are notoriously inaccurate and 2) research into the possible use of biological markers to remedy the self-report inaccuracies has hardly been extensive. I will attempt to determine if levels of gamma-glutamyl transpeptidase (GGTP), levels of urinary dolichols, or the quantification of carbohydrate-deficient transferrin (CDT) can be used as indicators of chronic excessive alcohol consumption or to monitor compliance with alcohol abstinence programs, particularly among women of child-bearing age. Subjects (approximately 30 female alcoholics and 30 female controls) will participate in an interview regarding drinking behavior, complete the Michigan Alcoholism Screening Test (MAST), consent to the interview of a significant other for corroboration, and provide both a blood and urine sample for subsequent analysis for GGTP activity, urinary dolichol levels, and CDT amount. A correlational analysis will be run to examine the correlation between self-report and biochemical levels. As well, levels of GGTP, urinary dolichols, and CDT will be compared to the established norms for nondrinkers and the known range for heavy consumers of alcohol.