BIOLOGICAL MARKERS OF ALCOHOL CONSUMPTION AMONG WOMEN

女性饮酒的生物标志物

• 批准号: 3422038
• 负责人: Linda S LaGrange
• 金额: $ 5.53万
• 依托单位: NEW MEXICO HIGHLANDS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 1993-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3422038
• 关键词: Hispanic Americans; alcoholic beverage consumption; alcoholism /alcohol abuse; biomarker; blood tests; dolichol; drug screening /evaluation; ethanol; female; glutamyltransferase; human pregnant subject; human subject; questionnaires; statistics /biometry; transferrin; urinalysis; young adult human (21-34)

APPLICANT'S ABSTRACT: Attempts of health and social care professionals to respond appropriately to the ever-increasing numbers of alcohol-related problems among women are handicapped by two important factors: 1) estimates of alcohol consumption based on self-report are notoriously inaccurate and 2) research into the possible use of biological markers to remedy the self-report inaccuracies has hardly been extensive. I will attempt to determine if levels of gamma-glutamyl transpeptidase (GGTP), levels of urinary dolichols, or the quantification of carbohydrate-deficient transferrin (CDT) can be used as indicators of chronic excessive alcohol consumption or to monitor compliance with alcohol abstinence programs, particularly among women of child-bearing age. Subjects (approximately 30 female alcoholics and 30 female controls) will participate in an interview regarding drinking behavior, complete the Michigan Alcoholism Screening Test (MAST), consent to the interview of a significant other for corroboration, and provide both a blood and urine sample for subsequent analysis for GGTP activity, urinary dolichol levels, and CDT amount. A correlational analysis will be run to examine the correlation between self-report and biochemical levels. As well, levels of GGTP, urinary dolichols, and CDT will be compared to the established norms for nondrinkers and the known range for heavy consumers of alcohol.

申请人的摘要：健康和社会护理专业人员尝试 适当响应与酒精相关的数量不断增加的 女性中的问题受到两个重要因素的残障：1） 众所周知，基于自我报告的饮酒估计值 不准确和2）研究可能使用生物标志物来 补救自我报告的不准确性并不广泛。 我会 尝试确定γ-谷氨酰基转肽酶（GGTP）的水平是否水平， 尿dolichols的水平，或定量 缺乏碳水化合物的转铁蛋白（CDT）可以用作指标 长期过度饮酒或监测酒精的依从性 禁欲计划，特别是在育龄妇女中。 受试者（大约30名女性酗酒者和30个女性对照）将 参加有关饮酒行为​​的采访，完成 密歇根州酒精中毒筛查测试（桅杆），同意采访 佐证的其他重要其他，并提供血液和尿液 样本以进行后续分析GGTP活性，尿Dolichol水平， 和CDT量。 将进行相关分析以检查 自我报告与生化水平之间的相关性。 同样， 将GGTP，尿Dolichols和CDT与已建立的规范进行比较 对于非养殖者和已知的大量酒精消费者范围。