CYTOKINES, LIPID MEDIATOR IN REGULATORS OF CELL FUNCTION

细胞因子、细胞功能调节剂中的脂质介质

• 批准号: 3433771
• 负责人: PATRICK Y-K WONG
• 金额: $ 1.1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1992-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3433771
• 关键词: cytokine; leukotrienes; lipids; platelet activation; prostaglandins; protein structure function; receptor binding; receptor expression; tumor necrosis factor alpha; tumor necrosis factor beta

Cytokines are protein mediators that are secreted from or surface expressed on lymphocyte-derived and mononuclear phagocytes in response to inflammation or immune antigens. All cytokines share a common mode of action by binding to specific receptors on the surface of the target cells. Certain cytokines will cause the release of second cytokines or lipid mediators that modulate the function of the target cells. The interaction of cytokines and lipid mediators can be inhibitory, additive, synergistic or even resulted in the generation of novel effects not seen with either individual cytokine or lipid mediator alone. Thus, the precise biological action of a cytokine will be determined by the interaction of other lipid mediators in order to fulfill its duty on the regulation of cell function. This will be the first conference ever held by the FASEB summer conference series dealing with the cellular function of the interaction of cytokines and lipid mediators such as prostaglandins, leukotrienes and PAF, etc. In view of the potent cellular function of various cytokines: (interleukins, tumor necrosis factor and macrophage colony stimulating factors, etc.) it is necessary to have a thorough understanding of the current knowledge of these factors and their relationship to the development of various pathophysiological states. The current interest on cytokines and their cellular functions is extremely high and is of current interest to the scientific community to have this kind of conference to bring scientists of two different active research areas together to discuss their ideas, thoughts and exchange information on the cutting edge of the most current biomedical topics in an open manner at a quiet and unique setting. No such conference was ever held by FASEB or any other association on the same or similar topic. In 1984, FASEB held a summer conference on "Immmopharmacology" with one or two topics similar and related to this conference. The unique feature of this conference will be the excellent program and invited speakers in these two areas of research. Thus, this conference as its predecessors, will serve to further stimulate both new and established investigators to new discoveries in this area of endeavor.

细胞因子是一种蛋白质介质， 在淋巴细胞衍生的和单核吞噬细胞上表达， 炎症或免疫抗原。 所有的细胞因子都有一个共同的模式， 通过与靶表面上的特定受体结合而起作用 细胞 某些细胞因子将引起第二细胞因子的释放， 调节靶细胞功能的脂质介质。 的 细胞因子和脂质介质的相互作用可以是抑制性的，相加的， 协同或甚至导致产生未见的新效应 单独使用单个细胞因子或脂质介质。 因此 细胞因子的精确生物学作用将由 其他脂质介质的相互作用，以履行其职责， 调节细胞功能。 这将是有史以来第一次举行的会议 由FASEB夏季会议系列处理细胞功能 细胞因子和脂质介质的相互作用 白藜芦醇、白三烯和PAF等 各种细胞因子的细胞功能：（白细胞介素，肿瘤坏死 因子和巨噬细胞集落刺激因子等）要 要彻底了解这些现有知识， 因素及其与各种发展的关系 病理生理状态。 目前对细胞因子及其 细胞功能非常高，是目前感兴趣的， 科学界举办这样的会议来吸引科学家 两个不同的活跃研究领域一起讨论他们的想法， 思想和交流信息的最新前沿 在一个安静和独特的环境中以开放的方式讨论生物医学主题。 没有 FASEB或任何其他协会就 相同或相似的主题。 1984年，FASEB举行了一次夏季会议， “免疫药理学”与此类似或相关的一两个主题 会议 本次会议的独特之处将是优秀的 计划和邀请演讲者在这两个领域的研究。 因此，这 会议作为其前身，将进一步促进新的 并建立了调查人员，以新的发现，在这一领域， 奋进。