THE CHEMISTRY AND BIOLOGY OF THE FGF

成纤维细胞生长因子（FGF）构成了一个家族， 结构上相关的多肽。 碱性成纤维细胞生长因子（bFGF）和酸性成纤维细胞生长因子 （aFGF）是该家族的最佳特征成员。 他们是 细胞增殖、运动、分化和增殖的有效调节剂， 生存 它们在体内的正常生理过程中起着重要的作用， 例如胚胎发育、血管生成和伤口修复。 此外，bFGF和aFGF是有效的神经营养因子。 一个可能 FGF家族在诸如癌症的病理过程中的作用， 随着最近发现几种癌基因已经被 鉴定出与bFGF和aFGF具有40-50%的序列同源性。 这些 癌基因包括int-2、hst、K-FGF和FGF-5。 基金的另一个成员 角质形成细胞生长因子（KGF）家族，是一种特异性促分裂原， 最近也描述了上皮细胞。 本次会议将 专注于FGF家族及其细胞的结构和功能 表面受体，以及它们的生物学、生理学和 体内病理学特性。 将详细讨论的主题 包括1）FGF家族的结构和生物学特性 (bFGF、aFGF、int-2、hst、K-fqf、FGF-5、FGF-6和KGF）， bFGF和aFGF，包括培养细胞的生物合成， 天然和改变的重组bFGF和aFGF，转录和 FGF合成的翻译调节和bFGF的定位， 细胞中的aFGF，3）受体和结合蛋白，包括结构 FGF高亲和力细胞表面受体和低亲和力细胞表面受体的功能 4）FGF的分布和功能 在各种组织如眼睛、心脏、肌肉、大脑和皮肤中， FGF与基质和基底膜的结合，5）FGF的作用 FGF家族成员在卵母细胞和胚胎发育中的作用，以及6）体内 以及FGF家族成员可能的临床作用。 这些应用 包括血管再内皮化、溃疡愈合、伤口 修复和神经元存活。 最后，FGF中使用的术语 这个领域经常令人困惑。 本次会议将允许与会者 推荐合适的命名法

The fibroblast growth factors (FGF) constitute a family of at least structurally related polypeptides. Basic FGF (bFGF) and acidic FGF (aFGF) are the best characterized members of this family. They are potent modulators of cell proliferation, motility, differentiation and survival. They play an important role in vivo in normal physiological processes such as embryonic development, angiogenesis, and wound repair. In addition, bFGF and aFGF are potent neurotrophic factors. A possible role for the FGF family in pathological processes such as cancer has become evident with the recent discovery that several oncogenes have been identified that have a 40-50% sequence homology to bFGF and aFGF. These oncogenes include int-2, hst, K-fgf and FGF-5. Another member of the FGF family, keratinocyte growth factor (KGF), a specific mitogen for epithelial cells has also been described recently. This meeting will focus on the structure and function of the FGF family and their cell surface receptors, as well as on their biological, physiological and pathological properties in vivo. The topics to be discussed in detail include 1) The structural and biological properties of the FGF family (bFGF, aFGF, int-2, hst, K-fqf, FGF-5, FGF.6 and KGF), 2) Biosynthesis of bFGF and aFGF including biosynthesis by cultured cells, expression of native and altered recombinant bFGF and aFGF, transcriptional and translational regulation of FGF synthesis and localization of bFGF and aFGF in cells, 3) Receptors and binding proteins including the structure and function of FGF high affinity cell surface receptors and low affinity receptors which are heparin-like, 4) The distribution and function of FGF in various tissues such as eye, heart, muscle, brain and skin as well as the association of FGF with matrix and basement membrane, 5) The role of FGF family members in oocyte and embryonic development, and 6) in vivo and possible clinical roles for FGF family members. These applications include reendothelialization of blood vessels, ulcer healing, wound repair, and neuronal survival. Finally, the nomenclature used in the FGF field has often been confusing. This meeting will allow the participants to recommend a suitable nomenclature.