GORDON RESEARCH CONFERENCE ON HORMONAL CARCINOGENESIS

这项提议要求提供资金，以协助支助第一个两年期 戈登激素致癌研究会议将在纽约举行 汉普顿学校，新罕布夏州，1985年8月25日至30日。这次会议的目的是 汇集了一系列多学科的实验系统，这些系统 与了解其致癌活性的共同目标有关 细胞和组织水平的激素内分泌器官和 目标组织。这将为不同的群体提供机会 生命科学家将在非正式讨论中分享他们的新想法和数据 并在这次会议的一周内进行询问。提供以下内容的主题 这些共同点是：(1)人类内分泌肿瘤的病因学--交易 类固醇和多肽与人子宫内膜和乳腺的关系 癌症；(2)细胞增殖--类固醇作用的最新研究 激素，特别是雌激素对靶细胞体外生长的影响 合成、受体结合、生长因子等；(3)细胞起源 内分泌肿瘤-处理当前的体外和体内研究 乳腺实质的细胞组成及其与血管生成的关系 激素依赖性和非依赖性肿瘤的起源；(4)类固醇化学 -处理修饰的类固醇及其在致癌和致癌中的作用 治疗；(5)两次类固醇雌激素和二苯乙烯类雌激素 处理可能的活性中间体的新陈代谢；(6)关于 雌激素与受体的构效关系 相互作用与致癌活性；(7)动物模型会议 雌激素诱发肿瘤的生化研究和(8)A 关于雌激素诱导细胞体外转化的会议。我们相信 这次会议不仅应该提供一个论坛来讨论最近 激素致癌方面的成就，但也应该增加新的流入和 在研究人员、概念和实验方面对该领域的活力 对于在这一领域继续取得进展至关重要的方法 重要的研究领域。

This proposal requests funds to assist in the support of the first biennial Gordon Research Conference on Hormonal Carcinogenesis to be held in the New Hampton School, New Hampshire, August 25-30, 1985. This meeting is to bring together a series of multidisciplinary experimental systems that are related by the common goal of understanding the carcinogenic activity of hormones at the cellular and organismal levels in endocrine organs and target tissues. This will provide an opportunity for a diverse group of life scientists to share their new ideas and data in informal discussion and enquiry during the week of this conference. The topics that provide this common ground are: (1) Etiology of human endocrine tumors - dealing with steroid and polypeptide involvement in human endometrial and breast cancer; (2) Cell proliferation - current studies on the role of steroid hormones, especially estrogens on growth of target cells in vitro, DNA synthesis, receptor binding, growth factors, etc.; (3) Cellular origin of endocrine tumors - dealing with current in vitro and in vivo studies on the cellular composition of the breast parenchyma and their relationship to the origin of hormone-dependent- and independent-tumors; (4) Steroid chemistry - dealing with modified steroids and their roles in carcinogenesis and in therapy; (5) Two sessions on Steroidal estrogen and Stilbene estrogen metabolism dealing with possible reactive intermediates; (6) One session on Structure activity relationships of estrogens in regard to receptor interactions and carcinogenic activity; (7) A session on animal models dealing with biochemical studies on estrogen-induced tumors and (8) A session on Estrogen-induced cell transformation in-vitro. We believe that this meeting should provide a forum not only for discussion of recent achievements in hormonal carcinogenesis, but should also add new influx and vigor to the field in terms of investigators, concepts, and experimental approaches which are essential for continued progress in this timely and significant research area.