SEVENTEENTH INTERNATIONAL HERPESVIRUS WORKSHOP

第十七届国际疱疹病毒研讨会

• 批准号: 3433625
• 负责人: S DIANE HAYWARD
• 金额: $ 1.18万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-15 至 1992-12-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3433625
• 关键词: Herpesviridae; Herpesviridae disease; travel; workshop

This proposal requests funds to enable young investigators to attend the 17th International Herpesvirus Workshop to be held at Heriott-Watt University, Edinburgh, Scotland from August 1-7, 1992. This workshop is the single most important meeting for the herpesvirus field. It attracts a broad-based international attendance of individuals with both basic science and clinical interests. The strength of the meeting lies in th high level of participation by researchers from diverse disciplines which promotes cross-fertilization of ideas, stimulates discussion and encourages exchange of information. Human herpesviruses cause a wide range of disease syndromes. Neoplasias such as nasopharyngeal carcinoma, B-cell lymphoma and Hodgkins Disease are all associated with Epstein-Barr virus (EBV). Infectious diseases such as skin and genital ulcerations are caused by herpes simplex (HSV) -1 and -2 respectively, eye ulcerations by HSV, infectious mononucleosis by EBV and chicken pox and shingles by varicella- zoster virus (VZV). Congenital infection with HSV-2 and cytomegalovirus (CMV) are significant causes of mental retardation while in infants human herpesvirus 6 (HHV6) infection produces a febrile illness, roseola infantum. Neurological disease includes HSV-1 encephalitis which can be devastating. The hallmark properties of herpesviruses, namely latency, persistence and reactivation, are central to their medical importance. Herpesviruses play an ever-increasing role as opportunistic infectious agents contributing to morbidity and mortality in the immuno-compromised. Organ (heart, lung and kidney) and bone marrow transplant recipients and AIDS patients are susceptible to EBV associated systemic and central nervous system lymphoma and oral infection (hairy leukoplakia), CMV retinitis and pneumonitis and disseminated CMV and to VZV infection. An emerging area is the development of defective, modified herpes viruses as vectors for gene therapy, with emphasis currently being placed on neuronal targeting. Animal herpesvirus have significant economic importance to the poultry (Marek's Disease virus), swine (pseudo-rabies virus), dairy (bovine rhinotracheitis virus) and equine (equine herpesviruses) industries. In addition simian herpesvirus saimiri and Marek's disease virus provide model systems for studying herpesvirus oncogenicity. Sessions will be offered on the following topics: Gene regulation, DNA replication, genome structure, enzymes and non-structural proteins, glycoproteins and structural proteins, receptors and virus entry, latency, transformation and neoplasia, immunology, viral pathogenesis, anti-virals and resistance, vaccines and prophylaxis and therapy.

这项提案要求提供资金，使年轻的调查人员能够参加 第17届国际疱疹病毒研讨会将在Heriott-Watt举行 1992年8月1日至7日，苏格兰爱丁堡大学。 这个研讨会是 疱疹病毒领域最重要的会议。 它吸引 一个基础广泛的国际参与的个人， 科学和临床兴趣。 会议的力量在于 来自不同学科的研究人员的高度参与， 促进思想交流，鼓励讨论，鼓励 交换信息。 人类疱疹病毒可引起多种疾病 综合征 肿瘤，如鼻咽癌、B细胞淋巴瘤 和霍奇金斯病都与EB病毒（EBV）有关。 皮肤和生殖器溃疡等传染病是由 单纯疱疹（HSV）-1和-2，HSV引起的眼溃疡， EB病毒引起的传染性单核细胞增多症水痘和水痘引起的带状疱疹 带状疱疹病毒（VZV）。 先天性单纯疱疹病毒2型和巨细胞病毒感染 (CMV)是智力迟钝的重要原因，而在婴儿中， 疱疹病毒6型（HHV 6）感染可引起发热性疾病，即玫瑰疹 婴儿 神经系统疾病包括HSV-1脑炎， 毁灭性的 疱疹病毒的标志性特征，即潜伏期， 持久性和再活化是其医学重要性的核心。 疱疹病毒作为机会性传染病， 在免疫功能低下的患者中导致发病率和死亡率的因素。 器官（心脏、肺和肾）和骨髓移植受者， 艾滋病患者易感染EB病毒相关的全身和中枢 神经系统淋巴瘤和口腔感染（毛状白斑），CMV 视网膜炎和肺炎以及播散性CMV和VZV感染。 一个 一个新兴领域是缺陷的、修饰的疱疹病毒的发展， 用于基因治疗的载体，目前重点放在神经元 面向. 动物疱疹病毒对人类具有重要的经济意义， 家禽（马立克氏病病毒）、猪（伪狂犬病病毒）、乳制品（牛 鼻气管炎病毒）和马（马疱疹病毒）产业。 在 此外，猴疱疹病毒saimiri和马立克氏病病毒提供了模型 研究疱疹病毒致癌性的系统。 会议将提供以下主题：基因调控，DNA 复制，基因组结构，酶和非结构蛋白， 糖蛋白和结构蛋白，受体和病毒进入，潜伏期， 转化和肿瘤形成，免疫学，病毒发病机制，抗病毒药物 和抗药性，疫苗，预防和治疗。