MASSAGING HIV-1-EXPOSED INFANTS

按摩暴露于 HIV-1 的婴儿

• 批准号: 3430162
• 负责人: FRANK A SCAFIDI
• 金额: $ 7.41万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-05-01 至 1994-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3430162
• 关键词: HIV infections; catecholamines; child behavior; child psychology; clinical chemistry; cognition disorders; cortisol; human subject; human therapy evaluation; immune system; postnatal growth disorder; premature infant human; psychomotor function; sleep; somatotropin; stress; touch; wakefulness

Massage facilities weight gain, state organization, social responsitivity and cognitive performance and reduces stress behaviors in preterm newborn infants. Touch has also been positively associated with changes in brain structure and improved immune functioning. Failure-to-thrive, poor immune functioning, and developmental and cognitive deficits are significant problems for the HIV-exposed infant. These data suggest using massage with HIV-exposed infants will facilitate weight gain, improve developmental performance and enhance immune functioning. Eight HIV-exposed preterm newborns will be randomly assigned to treatment (massage) and control conditions at the time they are transferred to the intermediate care units and are medically stable. The massage procedure used in our previous studies will be used in this study: three 15-minute periods of massage daily for a 10 day period. Sleep/wake behaviors (including stress behaviors such as facial grimaces, clenched fists and yawning) will be recorded and heart rate will be monitored on the first and last days of the study period to assess sleep/wake organization, activity and stress levels. Urine and blood samples will be collected on those days to assay cortisol, growth hormone and catecholamine levels. Developmental performance will be assessed using the Brazelton Neonatal Behavior Assessment Scale-Kansas Supplements. The parent/infant dyad will be followed in the UM Special Immunology Clinic at 3 and 6 months corrected age. Sleep/wake behavior, stress behavior and immune functioning will be assessed at each clinic visit. Bayley Scales of Infant Development also will be administered at 6 months corrected age. It is expected that the HIV--exposed preterm infants who are massaged will gain more weight, show superior developmental performance, exhibit fewer stress behaviors and have improved immune functioning.

按摩设施体重增加，国家组织，社会责任 和认知能力，并减少早产儿的压力行为 婴儿。 触摸也与大脑的变化呈正相关 改善免疫功能。 无法茁壮成长，免疫力差 功能，发育和认知缺陷是显着的 艾滋病暴露婴儿的问题。 这些数据表明，使用按摩与 暴露于艾滋病毒的婴儿将促进体重增加， 性能和增强免疫功能。 8例艾滋病毒暴露早产儿 新生儿将被随机分配到治疗（按摩）和对照组 在他们被转移到中间护理单位时的条件 病情稳定 我们之前的按摩程序 研究将用于这项研究：三个15分钟的按摩时间 每日一次，持续10天。 睡眠/觉醒行为（包括压力） 行为，如面部表情，握紧拳头和打哈欠）将是 记录并在第一天和最后一天监测心率， 研究期间评估睡眠/觉醒组织，活动和压力水平。 将在这些天收集尿液和血液样本以测定皮质醇， 生长激素和儿茶酚胺水平。 发展业绩将是 使用Brazelton新生儿行为评估量表-堪萨斯州进行评估 补充剂. UM特殊中将遵循父母/婴儿二元组合 3个月和6个月矫正年龄时的免疫学诊所。 睡眠/觉醒行为， 将在每个诊所评估应激行为和免疫功能 访问 贝利婴儿发育量表也将在6岁时进行 月校正年龄。 预计接触艾滋病毒的早产儿 被按摩的人会增加更多的体重，表现出上级的发育 性能，表现出更少的压力行为，并提高免疫力 功能