CSF-1, CSF-1 RECEPTOR, AND STEROIDS IN THE ENDOMETRIUM

肽生长因子及其受体都被认为是 性激素某些生理效应的潜在介体 激素对人体子宫内膜的影响。我们自己开展的前期工作 还有一些人认为：1)CSF-1(集落刺激因子)及其 受体存在于正常子宫内膜和肿瘤子宫内膜中，2) 这两种基因的表达可能都受到类固醇激素的控制。在……里面 这项申请我们建议延长我们正在进行的调查 卵巢癌和子宫内膜癌中脑脊液-1及其受体的生理学研究 R29-CA47292资助的正常子宫内膜，特别是研究 与此相关的生理和分子生物学关系 生长因子及其受体、性激素和糖皮质激素。

Peptide growth factors and their receptors have both been implicated as potential mediators of some of the physiologic effects of sex steroid hormones on human endometrium. Preliminary work carried out by ourselves and others suggest 1) that CSF-1 (colony stimulating factor) and its receptor are present in normal and neoplastic endometrium and 2) that expression of both genes may be under the control of steroid hormones. In this application we propose to extend our ongoing investigations on the physiology of CSF-1 and its receptor in ovarian and endometrial carcinomas funded by R29-CA47292 to normal endometrium, particularly to investigate the physiologic and molecular biological relationships involving this growth factor, its receptor, and sex and glucocorticoid steroid hormones.