权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

RESEARCH CONFERENCE--METALLOPROTEINASES

研究会议--金属蛋白酶

基本信息

批准号：
3434469
负责人：
HENNING BIRKEDAL-HANSEN
金额：
$ 3万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
1989
资助国家：
美国
起止时间：
1989-08-15 至 1990-08-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3434469
关键词：
collagenase extracellular matrix metalloenzyme peptidases

项目摘要

This proposal is for support of an international research conference on metalloproteinases and their role in extracellular matrix degradation in health and disease. The conference is unique and timely because of recent advances which have shown that matrix metalloproteinases constitute a family of genetically and functionally distinct but structurally homologous enzymes which play an important role in the biologic degradation of extracellular matrices. So far, five enzymes encoded for by a family of highly conserved genes have been identified: fibroblast-type IV collagenase, PMN-type collagenase, stromelysin, Mr 72,000 gelatinase/type IV collagenase, and Mr 95,000 gelatinase. The conference will summarize new and existing data on (1) structure and catalytic properties; (2) regulation of catalytic activity at the levels of gene expression, enzyme activation, and inactivation by natural and synthetic inhibitors; and (3) role in biologic degradation of extracellular matrices. The conference will provide for discussion of information and ideas to an extent not achievable by conventional means of communication, such as publication and more formal scientific meetings. We propose to bring together leading scientists from the U.S. and abroad for a 4 1/2 day conference to evaluate current knowledge and to discuss future avenues of research. A total of 55-60 invited speakers and moderators, each an expert in their field, will be asked to present a timely overview and new data on an assigned topic in their area of expertise. Speakers will also be requested to submit a written manuscript, and these will form the basis for publication of the proceedings of the conference. Poster sessions are planned to be open to those who wish to present new data.

本提案旨在支持国际研究会议金属蛋白酶及其在细胞外基质降解中的作用健康和疾病。由于最近的研究进展表明基质金属蛋白酶构成了遗传和功能不同但结构同源的家族酶在生物降解中起重要作用细胞外基质。到目前为止，由一个家族编码的五种酶高度保守的基因已被鉴定：成纤维细胞-IV型胶原酶、PMN型胶原酶、溶基质素、Mr 72,000明胶酶/型 IV胶原酶和Mr 95,000明胶酶。会议将总结新以及（1）结构和催化性能的现有数据；（二）监管基因表达、酶激活水平的催化活性，天然和合成抑制剂的失活； (3) 的作用细胞外基质的生物降解。会议将提供讨论信息和想法，达到无法达到的程度传统的沟通方式，例如出版和更正式的沟通方式科学会议。我们建议汇集来自世界各地的顶尖科学家美国和国外举行为期 4 1/2 天的会议来评估当前知识并讨论未来的研究途径。共55-60个受邀演讲者和主持人均是各自领域的专家，要求及时提供有关指定主题的概述和新数据他们的专业领域。演讲者还将被要求提交一份书面手稿，这些将构成出版的基础会议记录。海报会议计划向以下人士开放那些希望提供新数据的人。