MYELINATION AND DYSMYELINATION

由纽约科学院主办的一次会议 计划将研究细胞的研究人员聚集在一起， 髓鞘形成的分子方面。会议的主要焦点将是 髓磷脂突变体，因为他们提供了新的见解， 髓鞘形成的发育过程。在过去的五年里， 主要髓鞘蛋白的基因已经被克隆和测序， 已经鉴定了几种髓磷脂突变体的遗传基础。现代 蜂窝技术有助于确定事件的顺序 导致正常和/或异常髓鞘形成。 现在可以追踪 从已鉴定的遗传缺陷到其细胞表达的途径， 神经系统本次会议的目的是整合 从有关髓鞘形成的分子和细胞研究中获得的信息 形成一个连贯的模型，以确定我们对这一问题的理解存在的差距， 过程和规划未来的研究方向， 髓鞘形成上一次专门讨论髓鞘形成的会议是在 八年前，由于这一领域的爆炸性增长， 举行这样一次多学科会议是及时的。

A conference under the auspices of the New York Academy of Sciences has been planned to bring together investigators studying the cellular and molecular aspects of myelination. The major focus of the meeting will be the myelin mutants since they have provided new insights into the normal developmental process of myelin formation. Within the last five years, the genes for the major myelin proteins have been cloned and sequenced and the genetic basis for several of the myelin mutants has been identified. Modern cellular technologies have helped to identify the sequence of events leading to normal and/or abnormal myelination. It is now possible to trace the pathway from an identified genetic defect to its cellular expression in the nervous system. The intent of this conference is to integrate the information obtained from molecular and cellular studies about myelination into a coherent model, to identify the gaps in our understanding of this process and to plot future directions of research in the are a of myelinogenesis. The last conference devoted to myelinogenesis was held eight years ago and because of the explosive growth in this area, it is now timely to hold such a multidisciplinary meeting.