TEMPERATURE EFFECTS ON REMINERALIZATION OF ENAMEL CARIES

温度对牙釉质龋齿再矿化的影响

• 批准号: 3425237
• 负责人: JAMIE L SCHLOTTMANN
• 金额: $ 1.81万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1988-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3425237
• 关键词: calcification; calcification stimulant; dental caries; human tissue; ingested fluoride therapy; preventive dentistry; temperature; tooth; tooth enamel; topical fluoride therapy

Although in recent years, caries incidence has been reduced significantly, due predominantly to an increased use of fluoride, caries still remains a major health problem. The continued use of fluorides in their present form may have only limited value with respect to better levels of caries prevention. Since calcifying fluids are significantly more effective in the remineralization of carious lesions relative to fluoride alone, they may prove to be an important tool in combating caries in the future. Because of this, it is necessary to perform studies to develop new and better calcifying fluids and examine the mechanisms by which they work. This study will examine the effects of four temperature regimes on the two remineralizing fluids for which our group has the most data. Eight different combinations of temperature and calcifying fluids will be tested. The temperatures to be tested are 15 degrees, 25 degrees, 37 degrees and 50 degrees C. The fluids used in this experiment will contain 1mM and 3mM calcium with a calcium to phosphate ratio of 1.63. The differences in effects of the eight experimental regimens will be analyzed using polarized light microscopy and ultrastructural techniques developed by our group. This study will indicate the optimum temperature for remineralization using these two calcifying fluids and will determine whether more work in the area of temperature relationships is worth while.

虽然近年来，龋齿发病率有所下降 值得注意的是，主要由于氟化物的使用增加， 龋齿仍然是一个主要的健康问题。 继续使用 目前形式的氟化物可能仅具有有限的价值， 更好地预防龋齿。 由于钙化 液体在使 龋损相对于单独的氟，他们可能被证明是一个 未来防治龋齿的重要工具。 正因为如此， 有必要进行研究，以开发新的，更好的， 钙化液体并检查其工作机制。 本研究将探讨四种温度制度的影响 两种矿化液， 数据 八种不同的温度和钙化组合 将对液体进行测试。 测试温度为15 摄氏度、25度、37度和50度。 使用的流体 在本实验中将含有1mM和3mM钙， 钙磷比为1.63。 影响的差异 这八种实验方案将使用极化的 光学显微镜和超微结构技术， 组 这项研究将指出最佳温度为 使用这两种钙化液进行钙化， 确定是否在温度领域做更多工作 关系是值得的。