CELL SIGNALING AND THE MOLECULAR STRESS RESPONSE

环境毒素是一种重要的病原学决定因素， 各种疾病，包括器官变性和肿瘤。 虽然 暴露于环境压力急性毒性相对容易 以确定在高剂量下， 暴露于更现实水平的毒素在病因学、时间、 发病和可能的基本机制的行动。 在许多 慢性暴露综合征是一种基因表达的变化， 是由毒素引起的 识别相关基因和信号， 导致表达的变化将是未来的一个重大挑战 十年的环境研究。 阐明基因组对环境压力的反应将需要一个 通常不互动的个体之间的协调努力。 因此，在本发明中， 研究转录基本机制的分子生物学家需要 与环境科学家合作， 污染物不同领域的一些人最近的研究 如毒理学、分子生物学和细胞生物学， 集中在这个问题上，“细胞如何发出基因组反应的信号， 环境压力？“细胞信号传导与分子生物学”会议 压力反应，”结合了一个独特的群体的个人，并提供了一个 论坛的发言者和与会者集中注意分子 环境健康科学的方法。 小组讨论， 演讲者和受邀嘉宾将总结数据并概述机制 将这些知识应用于风险评估。这份摘要将予以公布。

Environmental toxins are important determinants in the etiology of a wide variety of diseases including organ degeneration and neoplasms. Although the acute toxicity of exposure to environmental stress is relatively easy to determine at high doses, the outcome of long term environmental exposure to more realistic levels of toxins differs in etiology, time of onset and probably the basic mechanisms of action. Underlying many of the chronic exposure syndromes is a change in gene expression which is signal led by the toxin. Identifying the relevant genes and the signals which lead to changes in expression will be a major challenge for the next decade of environmental research. Elucidating genomic responses to environmental stress will require a coordinated effort among individuals who do not normally interact. Thus, molecular biologists who study basic mechanisms of transcription will need to work with environmental scientists who are studying important pollutants. Recent studies by a number of individuals in diverse areas such as toxicology, molecular biology and cell biology have begun to converge on the question, "How do cells signal a genomic response to environmental stress?" The meeting on "Cell Signalling and the Molecular Stress Response," combines a unique group of individuals and provides a forum for both speakers and participants to focus attention on molecular approaches to the environmental health sciences. A panel discussion among speakers and invited guests will summarize the data and outline mechanisms to apply the knowledge to risk assessment. This summary will be published.