GORDON CONFERENCE--HORMONAL CARCINOGENESIS

戈登会议——荷尔蒙致癌

• 批准号: 3434310
• 负责人: SARASWATI SUKUMAR
• 金额: $ 0.9万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-26 至 1994-08-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3434310
• 关键词: cell cell interaction; cell growth regulation; chemical carcinogenesis; hormone related neoplasm /cancer; meeting /conference /symposium; molecular oncology; neoplasm /cancer epidemiology; oncogenes; travel; tumor suppressor genes

The aim of this conference is to provide a forum for authoritative investigators who are actively involved in the various disciplines which define the leading edges of research in hormonal carcinogenesis. It is important for such investigators to continue to meet regularly for the purpose of discussing the latest developments in their individual fields, to analyze the significance of current research, to discuss new tactics for unresolved problems, to critically evaluate current theories, and to develop new theories and approaches as needed. It has been estimated that 40-60% of human cancers are etiologically associated with sex hormone exposure, either endogenous or exogenous. The 1993 conference will focus on the mechanisms which regulate the proliferation, differentiation and transformation of cells. With reference to the specific tissues at risk for hormonally associated neoplasms, the conference will (1) discuss the underlying mechanisms associated with breast, prostate, ovary, uterus and vaginal, and liver cancer; (2) critically evaluate the role of cell differentiation defects in neoplasia; (3) consider key regulatory mechanisms (both positive and negative) by which hormones regulate growth and differentiation in normal cells, and consider how aberrations in these basic mechanisms might be causally related to neoplasia; (4) examine the regulation of genes involved with steroid biosynthesis, the metabolism of covalent intermediates as a possible mechanism of carcinogenesis; (5) define the neoplastic potential of estrogens and progestins in terms of the cell biology of development and cancer in target organs. Major themes are: (1) epidemiology, (2) control of cell growth by growth factors and interactions between growth factors and hormones; (3) the role of oncogenes in carcinogenesis; (4) stromal-epithelial interactions during growth control and carcinogenesis, and (5) negative as well as positive growth controls, e.g., inhibitory factors, or tumor suppressors. This conference is the major ongoing meeting that discusses hormonal carcinogenesis in a comprehensive, integrated fashion.

这次会议的目的是为权威人士提供一个论坛 积极参与各个学科的调查人员 定义荷尔蒙致癌研究的前沿。它是 重要的是，这些调查人员继续定期会面，以便 目的是讨论各自领域的最新发展， 分析当前研究意义，探讨新策略 对于未解决的问题，批判性地评估当前的理论，并 根据需要开发新的理论和方法。 据估计，40%-60%的人类癌症是由病因引起的 与性激素暴露有关，无论是内源性还是外源性。这个 1993年的会议将集中讨论规范 细胞的增殖、分化和转化。有参考价值 对于荷尔蒙相关肿瘤的风险特定组织， 会议将(1)讨论与以下方面相关的基本机制 乳腺癌、前列腺癌、卵巢癌、子宫癌、阴道癌和肝癌； 严格评估细胞分化缺陷在肿瘤形成中的作用； (3)考虑关键监管机制(包括积极和消极) 哪些激素调节正常细胞的生长和分化，以及 考虑一下这些基本机制中的像差是如何产生因果关系的 与肿瘤相关；(4)检测与肿瘤相关的基因的调控 类固醇的生物合成，共价中间体作为一种 致癌的可能机制；(5)定义肿瘤潜能 雌激素和孕激素在发育的细胞生物学中的作用 以及靶器官中的癌症。主要主题是：(1)流行病学，(2) 生长因子对细胞生长的调控及其相互作用 因素和激素；(3)癌基因在致癌中的作用；(4) 生长控制和癌变过程中的间质-上皮相互作用 以及(5)负的和正的生长控制，例如抑制 因子，或肿瘤抑制因子。 这次会议是正在进行的讨论荷尔蒙的主要会议。 以一种全面、综合的方式致癌。