GORDON CONFERENCE--HORMONAL CARCINOGENESIS

戈登会议——荷尔蒙致癌

• 批准号: 3434310
• 负责人: SARASWATI SUKUMAR
• 金额: $ 0.9万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-26 至 1994-08-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3434310
• 关键词: cell cell interaction; cell growth regulation; chemical carcinogenesis; hormone related neoplasm /cancer; meeting /conference /symposium; molecular oncology; neoplasm /cancer epidemiology; oncogenes; travel; tumor suppressor genes

The aim of this conference is to provide a forum for authoritative investigators who are actively involved in the various disciplines which define the leading edges of research in hormonal carcinogenesis. It is important for such investigators to continue to meet regularly for the purpose of discussing the latest developments in their individual fields, to analyze the significance of current research, to discuss new tactics for unresolved problems, to critically evaluate current theories, and to develop new theories and approaches as needed. It has been estimated that 40-60% of human cancers are etiologically associated with sex hormone exposure, either endogenous or exogenous. The 1993 conference will focus on the mechanisms which regulate the proliferation, differentiation and transformation of cells. With reference to the specific tissues at risk for hormonally associated neoplasms, the conference will (1) discuss the underlying mechanisms associated with breast, prostate, ovary, uterus and vaginal, and liver cancer; (2) critically evaluate the role of cell differentiation defects in neoplasia; (3) consider key regulatory mechanisms (both positive and negative) by which hormones regulate growth and differentiation in normal cells, and consider how aberrations in these basic mechanisms might be causally related to neoplasia; (4) examine the regulation of genes involved with steroid biosynthesis, the metabolism of covalent intermediates as a possible mechanism of carcinogenesis; (5) define the neoplastic potential of estrogens and progestins in terms of the cell biology of development and cancer in target organs. Major themes are: (1) epidemiology, (2) control of cell growth by growth factors and interactions between growth factors and hormones; (3) the role of oncogenes in carcinogenesis; (4) stromal-epithelial interactions during growth control and carcinogenesis, and (5) negative as well as positive growth controls, e.g., inhibitory factors, or tumor suppressors. This conference is the major ongoing meeting that discusses hormonal carcinogenesis in a comprehensive, integrated fashion.

本次会议的目的是为权威人士提供一个论坛 积极参与各个学科的研究人员 定义激素致癌研究的前沿。这是 对于此类调查人员来说，继续定期举行会议非常重要 讨论各自领域的最新发展的目的， 分析当前研究的意义，讨论新策略 对于未解决的问题，批判性地评估当前的理论，并 根据需要开发新的理论和方法。 据估计，40-60%的人类癌症是由病因引起的 与内源性或外源性激素暴露有关。这 1993年会议将重点讨论监管机制 细胞的增殖、分化和转化。有参考 对于有激素相关肿瘤风险的特定组织， 会议将 (1) 讨论与以下方面相关的基本机制： 乳腺癌、前列腺癌、卵巢癌、子宫癌、阴道癌以及肝癌； (2) 严格评估细胞分化缺陷在肿瘤形成中的作用； (3) 考虑关键的监管机制（积极的和消极的） 哪些激素调节正常细胞的生长和分化，以及 考虑这些基本机制中的畸变如何可能是因果关系 与肿瘤有关； (4)检查相关基因的调控 类固醇生物合成，共价中间体的代谢 可能的致癌机制； (5) 定义肿瘤潜能 雌激素和孕激素在细胞发育生物学方面的作用 和靶器官的癌症。主要主题是：（1）流行病学，（2） 生长因子控制细胞生长以及生长之间的相互作用 因素和激素； (3)癌基因在致癌过程中的作用； (4) 生长控制和癌变过程中基质-上皮相互作用， (5) 阴性和阳性生长对照，例如抑制性生长对照 因素，或肿瘤抑制因子。 这次会议是讨论荷尔蒙的主要持续会议 以全面、综合的方式致癌。