CLINICAL ASPECTS OF DE/REMINERALIZATION OF TEETH

该提案的目的是举行一次国际科学会议， 关于主题的会议（会议/讲习班）：牙齿的翻译 脱矿/矿化研究成果和技术 从实验室到临床应用于人类口腔。 短 标题将是“关于去/非商业化的临床方面的会议， 牙齿”。 会议/讲习班的目的是汇集专家， 牙齿去矿化和再矿化领域的研究人员（两者 实验室，即体外和动物，以及人体内区域）， 促进讨论和信息交流， 将现有和未来的知识转化为更有效的预防手段， 龋病 会议/讲习班的具体目标是： 1.评估牙齿领域的研究现状 与龋齿预防相关的去矿化/再矿化 (both冠状面和根面），特别是评估是否 DE/REMIN模型实际上代表了临床现实。 2.评估（a）体外模型的有效性和可靠性，（B） 动物模型，和（c）人类原位模型，作为 了解和预测临床龋齿研究的结果。 之一 最终目标将是在可能的情况下， 更长时间和更昂贵的临床试验的可靠模型。 3.评估这些模型在帮助确定 有龋齿风险的患者。 4.为临床研究制定新的研究议程， 脱矿和矿化。 5.建议新的和未来的研究计划，并优先考虑这些 以改进龋齿预防方法。 会议将于1994年6月在伍德克利夫会议上举行 中心，罗切斯特，纽约紧接在芝加哥IADR会议。 大约50名受邀与会者和50-100名自费观察员将 举行全体会议和个别讲习班小组会议， 达成共识，以实现上述具体目标和宗旨。 的 会议记录将被公布（最有可能在进展， 牙科研究）。

The purpose of this proposal is to hold an International Scientific Meeting (conference/workshop) on the topic: The translation of tooth demineralization/remineralization research findings and technology from the laboratory to clinical application in the human mouth. The short title will be "Conference on clinical aspects of de/remineralization of teeth". The objective of the conference/workshop is to bring together expert researchers in the area of tooth de- and remineralization (both laboratory, i.e. in vitro and animal, and human in vivo areas) to facilitate discussions and interchange of information that will transfer existing and future knowledge into more effective means of prevention of dental caries. The specific aims of the conference/workshop are: 1. To assess the current status of research in the area of tooth demineralization/remineralization as it relates to caries prevention (both coronal and root surface), and in particular, to assess whether de/remin models are actually representative of clinical reality. 2. To assess the validity and reliability of (a) in vitro models, (b) animal models, and (c) human in situ models as mechanisms for understanding and predicting outcomes of clinical caries studies. One of the ultimate goals will be the substitution, where possible, of valid and reliable models for more lengthy and costly clinical trials. 3. To assess the usefulness of these models to assist in identifying patients at risk (of dental caries). 4. To develop a new research agenda for clinical studies of demineralization and remineralization. 5. To recommend new and future research initiatives and prioritize these to improve caries preventive methods. The conference will be held in June, 1994 at the Woodcliff Conference Center, Rochester, NY immediately following the IADR meeting in Chicago. Approximately 50 invited participants and 50-100 self-pay observers will meet in plenary sessions and individual workshop groups to produce a consensus to fulfill the above specific aims and objectives. The conference proceedings will be published (most likely in Advances in Dental Research).