GORDON CONFERENCE--FIBRONECTIN AND MACROMOLECULES

戈登会议--纤连蛋白和大分子

• 批准号: 3435740
• 负责人: Mark HOWARD Ginsberg
• 金额: $ 1.2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-02-01 至 1994-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3435740
• 关键词: extracellular matrix proteins; fibronectins; integrins; meeting /conference /symposium; protein structure function; travel

The paradigm of an extracellular adhesin, fibronectin, interacting with a transmembrane receptor has proven applicable to a number of adhesion systems. There are several other extracellular glycoproteins with biological properties like fibronectin, laminin, thrombospondin, von Willebrand factor, fibrinogen/fibrin, vitronectin, and cytotactin/tenascin/hexabrachion. The primary structures of each of these proteins are determined and three-dimensional structures are in progress for some. This will open up new possibilities for studies of function. In parallel has come the realization that the transmembrane receptor for fibronectin is only one member of the integrin family of functionally related, homologous, cell adhesion receptors. Fibronectin and related macromolecules are involved in many basic functions of cells, including cell adhesion, determination of cell shape and differentiation, cell migration, cytoskeletal organization, and organization of extracellular matrix. Thus, fibronectin and the molecules with which it interacts are important in embryogenesis, connective tissue organization, hemostasis, thrombosis, wound healing, development of immunity, hematopoiesis, malignant transformation, and tumor metastasis. The challenges to the field over the next several years are to comprehend and organize the large amount of new structural information and design experiments based upon it; learn the relative biological importance of the several seemingly redundant adhesion systems; and apply the new insights to the treatment of human diseases. The 1993 Gordon Research Conference will serve as a valuable forum to present and discuss new information, identify problem areas, and plan new approaches.

细胞外粘附素，纤维连接蛋白，与细胞外基质相互作用的范例， 跨膜受体已被证明适用于许多粘附 系统. 还有几种其他的胞外糖蛋白， 生物学特性，如纤连蛋白、层粘连蛋白、血小板反应蛋白、血管内皮细胞生长因子等。 维勒布兰德因子、纤维蛋白原/纤维蛋白、玻连蛋白和 细胞增殖素/腱生蛋白/六臂蛋白。 每一个的主要结构 这些蛋白质被确定，并且三维结构被确定。 对于一些人来说，进步。 这将为研究 功能 与此同时，人们认识到， 纤连蛋白受体只是整合素家族的一个成员， 功能相关的同源细胞粘附受体。 Fibronectin 和相关的大分子参与细胞的许多基本功能， 包括细胞粘附、细胞形状和分化的确定， 细胞迁移、细胞骨架组织和 细胞外基质 因此，纤连蛋白及其与之结合的分子 相互作用在胚胎发生、结缔组织组织形成 止血，血栓形成，伤口愈合，免疫力的发展， 造血、恶性转化和肿瘤转移。 的 未来几年该领域面临的挑战是理解和 组织大量的新结构信息和设计 基于它的实验;学习相对生物学的重要性， 几个看似多余的粘附系统;并应用新的 对人类疾病治疗的见解。 1993年戈登研究 会议将作为一个宝贵的论坛，提出和讨论新的 信息，识别问题领域，并计划新的方法。