GORDON RESEARCH CONFERENCE ON LYSOSOMES

关于溶酶体的戈登会议将提供一个非正式论坛， 讨论细胞中的当前进展和新方向， 细胞内细胞器的分子生物学 将特别注意 病理生理过程的基础上畸变， 亚细胞结构和功能。 会议将专门讨论 细胞对新合成的蛋白质进行分类的机制;囊泡的 运输和驱动细胞中囊泡运动的马达蛋白; 细胞器和溶酶体的生物发生和细胞内的新方向 靶向;受体介导的内吞作用和 融合事件沿着内吞途径;抗原和蛋白质 以及某些微生物 逃避免疫破坏;通过溶酶体和 细胞质蛋白酶和蛋白质在这两者之间的运动 隔间 最后，将组织一次会议，讨论 我们对溶酶体储积病的理解，特别强调 所涉及的机制和使用转基因动物的研究， 酶替代疗法 我们将特别努力， 年轻的研究人员对该计划，并鼓励这些人， 参加计划在下午举行的两个海报会议之一。 此外，将从海报中挑选年轻的研究人员 在每届会议上向全体工作组介绍其工作， sessions. 这应能最大限度地传播新数据 并应允许年轻工人与那些在 互补的学科。 我们要求本申请由细胞生物学研究 科，一个在这一领域具有特殊专长的小组。 我们还将 像这个被几个NIH考虑部分资助的提案 除了NIGMS之外，还有其他机构。 的参与。溶酶体和 其他涉及分泌、加工和 各种疾病状态的病理生理学中的内吞作用将 成为会议的重要组成部分。 的多样性 提出的方案应允许个人广泛参与 具有不同的研究兴趣。

The Gordon Conference on Lysosomes will provide an informal forum for discussion of current advances and new directions in the cell and molecular biology of intracellular organelles. Special attention will be paid to pathophysiologic processes which are based on aberrations in subcellular structure and function. Sessions will be devoted to the mechanisms by which cells sort newly synthesized proteins; vesicular transport and the motor-proteins that drive vesicle movement in cells; organelle and lysosome biogenesis and new directions in intracellular targeting; receptor-mediated endocytosis and the reconstitution of fusion events along the endocytic pathway; antigen and protein processing by immune cells and the mechanisms by which certain microbes evade immune destruction; selective protein turnover by lysosomal and cytoplasmic proteases and the movement of proteins between these two compartments. Finally, a session will be organized on the progress in our understanding of lysosomal storage diseases with special emphasis on the mechanisms involved and the use of transgenic animals for studies of enzyme replacement therapy. We will make special effort to include young investigators on the program and to encourage such individuals to participate in one of two poster sessions planned for the afternoons. Additionally, young investigators will be selected from the poster session to present their work to the assembled group in each of the sessions. This should allow for the maximum dissemination of new data and should allow young workers to make important contacts with those in complementary disciplines. We request that this application be reviewed by the Cell Biology Study Section, a group with special expertise in this area. We also would like this proposal considered for partial funding by several NIH institutes in addition to NIGMS. The involvement of . lysosomes and other intracellular compartments involving secretion, processing and endocytosis in the pathophysiology of a variety of disease states will be a significant overall part of the meeting. The diversity of the program presented should allow for wide participation of individuals with diverse research interests.