CENTRE FOR DOCTORAL TRAINING IN THE EPSRC CENTRE FOR INNOVATIVE MANUFACTURING IN EMERGENT MACROMOLECULAR THERAPIES

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The focus of the proposed EPSRC CDT will be on manufacturing research and training required in the most rapidlydeveloping parts of the UK bio-centred pharmaceutical and healthcare biotechnology sector, that have major implicationsfor future medicine. The bioprocess industry manufactures novel macromolecular drugs, proteins, to address a broad rangeof chronic and debilitating human diseases. The UK holds a leading position by virtue of its science base and has unique university capabilities underpinning the sector. Whilst revenues are large, ~£110bn in 2009 on a worldwide basis, there arehuge pressures on the industry for change if demands for cost reduction and waste minimisation are to be met, andpopulations are to benefit from the potent drugs becoming available. A sea change in manufacturing will be needed overthe next decade if the potential of modern drugs are to make their way through to widespread distribution. Moreover this isa widely accepted skills shortage of individuals with the manufacturing research training needed for the sector.Alignment to the EPSRC Centre for Innovative Manufacturing in Emergent Macromolecular Therapies will deliver increasednational capability through training of the next generation of highly skilled and talented bioprocess manufacturingresearchers. Our aim is to train bioprocess engineering leaders of the future who will underpin translation of new scientificadvances into safely produced, more selective, therapies for currently intractable conditions at affordable costs. To achievethis we will embed CDT PhDs within the vibrant research community of the top UK Institutions and that of the EPSRCCentre for Innovative Manufacturing in Emergent Macromolecular Therapies, to ensure that they benefit in terms of impactand knowledge transfer from the links to research led companies. The gearing in of these collaborations will enable theCDT to explore new and emerging ideas in a training environment that draws on research excellence and to create strongsynergy between the Centre research programmes.