PHYSIOLOGIC ROLES FOR EGF, TGF-ALPHA AND THEIR RECEPTOR

表皮生长因子(EGF)是30年前在小鼠体内发现的 颌下腺。直到最近，EGF的生理作用才得到证实 系统开始被理解。为一次会议申请资金， EGF系统的生理作用：EGF、转化生长因子-α和EGF 虽然已经就EGF系统举行了几次会议， 这是独一无二的，因为它在体内的生理作用是主要的 主题。出席人数限制为60人，他们来自不同的 学科，确保经验丰富的和新的之间的互动 调查人员。将有7次会议，每次有4至7次口头交流 演讲和公开讨论。前两个介绍和概述，以及 更新有关EGF系统的信息。接下来的4个将是聚光灯 关于EGF系统如何发挥作用的数据正在出现的特定器官 在正常的生理机制中；这些是口腔和消化 肠道、神经系统、肾脏和生殖系统。这个 最后介绍了EGF系统的转基因和突变。关于EGF的数据 未被充分调查的器官中的系统将在海报中探索 会议。EGF系统在特定器官生理学中的研究现状 在某种程度上是彼此独立发展的。它是一名本金 这次会议的目标是将来自不同背景的工人聚集在一起 向：1)相互通报他们在体内功能的发现 EGF、转化生长因子-α及其受体；2)生成一个统一的视图 EGF系统的生理学；以及3)制定目标、方向和 未来研究的策略。一个同样重要的目标是 强调唾液研究对当前发展的影响 生物医学研究总体而言。表皮生长因子最早是从 颌下腺，其最早的影响之一是加速 门牙喷发的痕迹。随后演示了广泛的分布 EGF系统的研究很早就表明了一些非常基本的生理作用 因为它--其中一些现在开始被理解，它们是 拟议会议的主要议题。

Epidermal growth factor (EGF) was discovered 30 years ago in murine submandibular glands. Only recently have physiologic actions of the EGF system begun to be understood. Funding is requested for a conference, "The Physiologic Roles of the EGF System: EGF, TGF-alpha, and the EGF Receptor". Although there have been several meetings on the EGF system, this one is unique in having its in vivo physiologic roles as the primary topic. Attendance is limited to 60 participants from a variety of disciplines, to insure interaction between seasoned and new investigators. There will be 7 sessions, each with 4 to 7 oral presentations and open discussion. The first 2 present and overview, and update information on the EGF system. The next 4 will spot-light specific organs where data are emerging on how the EGF system functions in normal physiologic mechanisms; these are the Oral Cavity and Digestive Tract, the Nervous System, the Kidney, and the Reproductive Systems. The last covers transgenics and mutants of the EGF system. Data on the EGF system in less fully investigated organs will be explored in a poster session. Current data on the EGF system in specific organ physiology have developed somewhat independently of each other. It is a principal goal of this conference to bring workers from varied backgrounds together to: 1) inform each other of their findings on the in vivo functions of EGF, TGF-alpha, and their receptor; 2) generate a unified view of the physiology of the EGF system; and 3) formulate aims, directions and strategies for future research. An equally important goal is to underscore the impact of salivary research on current developments in biomedical research in general. EGF was first isolated from submandibular glands, and one of its first effects noted was acceleration of incisor eruption. Subsequent demonstration of the wide distribution of the EGF system has long indicated some very basic physiologic roles for it--some of these are now beginning to be understood, and they are the primary topic of the proposed conference.