CONFERENCE ON STEROID/THYROID RECEPTOR SUPERGENE FAMILY

类固醇/甲状腺受体超基因家族会议

• 批准号: 3434699
• 负责人: JOHN A. CIDLOWSKI
• 金额: $ 0.53万
• 依托单位: KEYSTONE CENTER
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-02-01 至 1993-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3434699
• 关键词: endocrinology; meeting /conference /symposium; molecular genetics; steroid hormone receptor; travel

Steroid/thyroid receptors play a crucial role in development, differentiation and maintenance of homeostasis in diverse species. The recent molecular cloning of many of the members of this supergene family has led to rapid expansion of research activities in this field and a considerable increase in our basic understanding of how these ligand-dependent transcription factors regulate gene expression. The development of efficient expression systems has now permitted the production of sufficient quantities of these receptors for analysis of in vitro gene transcription and for physical-chemical studies. The major problems facing the field of molecular endocrinology today are to understand the precise details of how steroid-thyroid receptors interact with DNA and other transcription factors to control gene expression, and to define the precise roles of receptor associated proteins (heat shock, etc.) and post transcriptional modification (phosphorylation) on receptor function. Comprehension of hormone action will require a complete understanding of the regulation of receptor gene expression and the role of receptors during development. The proposed program will facilitate addressing these issues by bringing together the foremost authorities on the steroid-thyroid receptor supergene family for the first time since the cloning of the genes. Additionally, we seek support to encourage participation of young scientists in early stages of their career development (graduate students, postdoctoral fellows, assistant professors) who will be future contributors to this important area of medical sciences. Interaction of these young investigators with established leaders in the field should provide an environment that will result in significant scientific discoveries. In the organization of this meeting, we will also take a unique comparative approach to each topic so as to permit optimal communication among researchers studying various members of the supergene families. Such a meeting should set the stage for the next era of research on these important regulatory molecules.

类固醇/甲状腺受体在发育中起着至关重要的作用， 在不同物种中的分化和维持稳态。 的 最近对这个超基因家族的许多成员进行了分子克隆 导致这一领域的研究活动迅速扩大， 我们对这些问题的基本认识有了相当大的提高 配体依赖性转录因子调节基因表达。 的 高效表达系统的发展现在已经允许 产生足够量的这些受体用于分析 体外基因转录和物理化学研究。 主要 当今分子内分泌学领域面临的问题是 了解类固醇-甲状腺受体如何相互作用的精确细节 与DNA和其他转录因子一起控制基因表达， 定义受体相关蛋白的确切作用（热休克等） 和转录后修饰（磷酸化） 功能 了解激素的作用需要一个完整的 了解受体基因表达的调节和 发育过程中的受体。 该计划将促进 解决这些问题，将最重要的权威聚集在一起， 类固醇甲状腺受体超基因家族，这是自2000年以来的第一次。 基因的克隆。 此外，我们寻求支持，鼓励 青年科学家在其职业生涯早期阶段的参与 发展（研究生、博士后、助理教授） 他们将成为医学科学这一重要领域的未来贡献者。 这些年轻的研究人员与该领域的知名领导人的互动 外地应提供一个环境， 科学发现。 在组织这次会议时，我们还将 对每个专题采取独特比较办法， 研究表基因不同成员的研究人员之间的交流 家庭 这样的会议应该为下一个研究时代奠定基础 这些重要的调节分子。