EPSRC-Royal Society fellowship engagement (2012): Development of Chemical Tools for Probing Histone Demethylases

EPSRC-皇家学会奖学金参与（2012）：开发用于探测组蛋白去甲基化酶的化学工具

• 批准号: EP/L003376/1
• 负责人: Akane Kawamura
• 金额: $ 38.19万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FL003376%2F1
• 关键词: EPSRC; Royal; Society; fellowship; engagement

Please refer to attached Royal Society application

请参阅附件中的皇家学会申请表

项目成果

Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins.

• DOI: 10.1038/s42004-022-00640-4
• 发表时间: 2022-12
• 期刊: Communications chemistry
• 影响因子: 5.9
• 作者: Belle R;Kamps JJAG;Poater J;Kumar K;Pieters BJGE;Salah E;Claridge TDW;Paton RS;Matthias Bickelhaupt F;Kawamura A;Schofield CJ;Mecinović J
• 通讯作者: Mecinović J

Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.

• DOI: 10.1002/anie.201706788
• 发表时间: 2017-12-04
• 期刊: Angewandte Chemie (International ed. in English)
• 作者: Gerken PA;Wolstenhulme JR;Tumber A;Hatch SB;Zhang Y;Müller S;Chandler SA;Mair B;Li F;Nijman SMB;Konietzny R;Szommer T;Yapp C;Fedorov O;Benesch JLP;Vedadi M;Kessler BM;Kawamura A;Brennan PE;Smith MD
• 通讯作者: Smith MD

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.

• DOI: 10.1039/c4md00291a
• 发表时间: 2014-12-01
• 期刊: MedChemComm
• 作者: England KS;Tumber A;Krojer T;Scozzafava G;Ng SS;Daniel M;Szykowska A;Che K;von Delft F;Burgess-Brown NA;Kawamura A;Schofield CJ;Brennan PE
• 通讯作者: Brennan PE

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.

• DOI: 10.1021/acs.jmedchem.5b01635
• 发表时间: 2016-02-25
• 期刊: Journal of medicinal chemistry
• 影响因子: 7.3
• 作者: Bavetsias V;Lanigan RM;Ruda GF;Atrash B;McLaughlin MG;Tumber A;Mok NY;Le Bihan YV;Dempster S;Boxall KJ;Jeganathan F;Hatch SB;Savitsky P;Velupillai S;Krojer T;England KS;Sejberg J;Thai C;Donovan A;Pal A;Scozzafava G;Bennett JM;Kawamura A;Johansson C;Szykowska A;Gileadi C;Burgess-Brown NA;von Delft F;Oppermann U;Walters Z;Shipley J;Raynaud FI;Westaway SM;Prinjha RK;Fedorov O;Burke R;Schofield CJ;Westwood IM;Bountra C;Müller S;van Montfort RL;Brennan PE;Blagg J
• 通讯作者: Blagg J

KDM4A regulates HIF-1 levels through H3K9me3.

• DOI: 10.1038/s41598-017-11658-3
• 发表时间: 2017-09-11
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Dobrynin G;McAllister TE;Leszczynska KB;Ramachandran S;Krieg AJ;Kawamura A;Hammond EM
• 通讯作者: Hammond EM