IMMUNOCHEMISTRY OF HLA-CONTROLLED SB ANTIGENS

人类HLA-D区调控的分子在免疫中的作用 反应性，并在移植排斥反应中具有临床重要性， 疾病易感性 这个项目的目标是研究基因 这个地区的复杂性。 这项研究将集中在免疫化学的 SB抗原 这些抗原由与DR连锁的基因座控制， 在分子结构和表达上与DR抗原非常相似。 将分离SB抗原，并使用 氨基酸测序和肽图谱。 这些研究应该阐明 控制两种复合物表达的基因座的数量和 SB和DR位点之间的关系。 SB抗原多态性将是 使用类似的程序进行检查。 对分子的理解 这些抗原的生物学特性在解释血清学和 HLA-D区域的功能研究。 这一地区与 各种各样的遗传性破坏性疾病和表征 抗原如SB将有助于该复合物的功能解剖 地区

Molecules controlled by the human HLA-D region function in immune responsiveness and have been clinically important in graft rejection and disease susceptibility. The goal of this project is to examine the genetic complexity of this region. This study will focus on the immunochemistry of the SB antigens. These antigens, controlled by a locus linked to DR, closely resemble the DR antigens in molecular structure and expression. The SB antigens will be isolated and compared to the DR antigens using amino acid sequencing and peptide mapping. These studies should elucidate the number of loci controlling the expression of the two complexes and the relationship between the SB and DR loci. SB antigen polymorphism will be examined using similar procedures. An understanding of the molecular biology of these antigens will be important in interpreting serological and functional studies of the HLA-D region. This region has been implicated in a wide variety of inheritable devastating diseases and characterization of antigens such a SB will aid in the functional dissection of this complex region.