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IMMUNE RESPONSE TO THERAPEUTIC TOUCH DURING STRESS

压力期间对治疗性触摸的免疫反应

基本信息

批准号：
3444210
负责人：
MELODIE A OLSON
金额：
$ 2.98万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
起止时间：
1993-09-30 至 1994-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3444210
关键词：
Haemophilus influenzae vaccines T cell receptor T lymphocyte alternative medicine anxiety emotions human subject human therapy evaluation immunoglobulins mitogens physical therapy psychological stressor psychological tests psychoneuroimmunology receptor expression stress touch university student

项目摘要

The specific aim of this study is to evaluate the effectiveness of Therapeutic Touch in reduction of selected stress-related decrements in immunocompetence (thereby improving immunocompetence) in a sample of highly stressed students facing their professional board exams. Immunocompetence will be measured by: function of T-lymphocytes and receptor expressiveness as measured by (1), responsiveness to mitogens; and (2), the ability of the body to mount an immune response to the hemophilus vaccine; and levels of immunoblobulins and their sub-classes. This builds on the work of Workman and LaVia, Glaser and Kiecolt & Glaser, and others who have demonstrated that stress effects immunocompetence in medical students. Long-term goals are to develop a model by which a variety of stress reduction approaches can be tested for efficacy, particularly in populations of immunosuppressed individuals. This design will be useful for testing a variety of nursing and alternative interventions in populations of highly stressed people, including newly diagnosed cancer patients, those with AIDS, and any other disease condition in which stress compromises the ability of the individual to heal. The repeated measures, repeated sessions experimental design will compare 20 subjects who are highly stressed as determined by Spielbergers' State/trait Anxiety Index (SSTAI), over a six month period. Both nursing and medical students will be recruited prior to board exams. Subjects will be randomly assigned to an experimental or control group. Data collection occurs four times: six months before the exams; before and after the set of three intervention sessions, occurring the week before boards; and, three weeks after the administration the hemophilus vaccine. Data collection includes those cited above (SSTAI and immunological profile), the Profile of Mood States (POMS), impact of Events Scale and standard demographic information. Data related to the major hypothesis are the immunological profiles between two groups which will be tested for differences. Correlation between the immunological profile and state and trait anxiety, the six sub scales of the POMS, and the impact of Events scales, will be determined.

这项研究的具体目的是评估治疗性触摸在减少所选应激相关减量中的作用免疫活性(从而提高免疫活性)的样本压力很大的学生面临着专业的董事会考试。免疫活性将通过：T淋巴细胞的功能和受体的表达能力由(1)，对有丝分裂原的反应性来衡量；和(2)身体对人体免疫反应的能力嗜血杆菌疫苗；免疫球蛋白及其亚类的水平。这是建立在Workman和LaVia，Gaser和Kiecolt&Gaser的工作基础上的，以及其他已经证明应激影响免疫能力的人医科学生。长期目标是开发一种模式，通过这种模式，各种压力可以测试减少方法的有效性，特别是在免疫抑制个体的群体。这个设计会很有用的用于测试各种护理和替代干预措施高压力人群，包括新诊断的癌症患者、艾滋病患者和任何其他有压力的疾病状况损害了个体的治疗能力。将重复测量、重复实验设计进行比较斯皮尔伯格确定的20名高度紧张的受试者状态/特质焦虑指数(SSTAI)，为期六个月。两者都是护理医科学生将在董事会考试之前被录取。研究对象将被随机分配到试验组或控制组。数据收集发生四次：考试前六个月；考试前后在董事会前一周举行的三次干预会议；以及接种后三周接种嗜血杆菌疫苗。数据收集包括上面引用的(SSTAI和免疫学概况)，情绪状态概况(POMS)、事件影响量表和标准人口统计信息。与主要假设相关的数据是两组人之间的免疫学特征将被检测不同之处。免疫学特征与状态和特质焦虑、POMS的六个子量表以及事件的影响规模，将被确定。