EPSRC Centre for Doctoral Training in Physical Sciences Innovation in Chemical Biology for Bioindustry and Healthcare

化学生物学是英国一个具有重要战略意义的研究领域，它着眼于研究生物系统中分子相互作用的新工具和技术的开发和应用。化学生物学的研究生培训将在推动生物技术和医疗技术、农业科学和个人护理部门的创新和改变设计流程，以及刺激在英国创建新的初创企业方面发挥关键作用。为了达到这些技能，必须培养新一代化学生物学博士毕业生，他们能够连接科学和商业/工业部门，同时仍然非常有能力在物理和生命科学界面上工作，允许多种形式的翻译活动。在帝国理工学院世界领先的化学生物学研究所(ICB)的多学科环境的支持下，新的CDT将在未来5年内培养90名博士生，以解决这一关键的技能差距。化学生物学的多学科性质以及它对在物理和生命科学以及学术和商业世界之间工作的学生构成的翻译挑战，使CDT结构非常适合支持学生的发展。在这一界面上的这种多学科培训对于使英国能够适应生活、个人护理和农业科学部门的技术变化速度至关重要。此外，与支撑这些新技术的研究相关的特定社会、伦理、工业和企业方面，需要一种在CDT背景下最有效地交付的定制方法。ICB及其战略合作伙伴共同制定了一个为期4年的培训和研究计划(MRES+3年博士学位)，该计划将提供多学科翻译研究、研究领导、科学交流、创业精神和商业技能的第一手经验。这包括在FAB实验室类型的环境中进行技术开发，与BBC合作进行科学交流培训，行业主导的创新研讨会，创业培训和学生主导的知识产权的“龙穴”式比赛。此外，我们将实施演进计划，这是一个为个人量身定做的旅程，旨在提供创业活动、政策制定、媒体/外展、工业研究或国际学术机构内的研究经验，以实现CDT学生选择的特定目标。这个紧密联系的学生群体将得到帝国理工学院所有三个学院120多个研究小组的支持。新的翻译分子研究专用实验室(LTMR)将进一步加强这些活动。CDT研究方案将产生的工具和技术将通过开发新的功能筛选、靶标验证分析、预测性人工仿生模型以及对潜在新靶点的洞察，支持药物、农化和个人护理产品的发现。他们还将协助和推动基础生物学、诊断技术、用于生物分子无标记跟踪的光学指纹技术、具有定制释放动力学的智能生物递送系统、小分子-膜蛋白筛选分析、药物分子非特异性结合的体外筛选、生物标志物的发现，并提供一套新的定量动态分子信息。

Chemical Biology is a strategically important area of research for the UK that looks at the development and application of novel tools and techniques for the study of molecular interactions in biological systems. Graduate training in Chemical Biology will play a crucial role in driving innovation and transforming the design process in the biotech and medical technology, agri-science and personal care sectors, as well as stimulating the creation of new start-up enterprises in the UK. In order to meet these skills a new generation of PhD graduates in Chemical Biology must be trained who are able to connect the scientific and commercial/industrial sectors whilst still being supremely well equipped to work across the Physical and Life Sciences interface, allowing for multiple forms of translational activity. This crucial skills gap will be addressed by the new CDT in "Physical Sciences Innovation in Chemical Biology for Bioindustry and Healthcare" which will train > 90 PhD students over the next 5 years, supported by the multi-disciplinary environment of the world leading Institute of Chemical Biology (ICB) at Imperial College.The multidisciplinary nature of Chemical Biology and the translational challenges that it poses to students working at the interface between the physical and life sciences and between the academic and commercial worlds makes a CDT structure highly appropriate for supporting student development. Such multi-disciplinary training at this interface is vital to enabling the UK to adapt to the pace of technological change in the life, personal care and agri-sciences sectors. Furthermore, the particular societal, ethical, industrial and entrepreneurial aspects associated with research that will underpin these new technologies requires a bespoke approach that is most effectively delivered in a CDT context. The ICB and its strategic partners have together crafted a 4-year training and research programme (MRes + 3 Year PhD), which will provide first-hand experience of multi-disciplinary translational research, research leadership, science communication, entrepreneurialism and business skills. This includes technology development in Fab lab type environments, science communication training in collaboration with the BBC, industry led innovation workshops, entrepreneurship training and a "Dragons Den"-type competitions for student-led IP. In addition, we will implement the EVOLVE programme, a journey tailored to the individual designed to give experience of entrepreneurial activities, policy making, media/outreach, industrial research, or research within international academic institutions in the context of achieving a particular goal selected by the CDT student.This closely knit cohort of students will be supported by an integrated community of over 120 research groups from all three faculties across Imperial College. These activities will be further enhanced by the new dedicated Laboratory for Translational Molecular Research (LTMR).The tools and technologies that will emerge from the research programme of the CDT will support drug, agrichemical and personal care product discovery through the development of new functional screens, target validation assays, predictive artificial biomimetic models and by providing insights into potential novel targets. They will also assist and advance basic biology, diagnostic technologies, optical finger printing technologies for label free tracking of biomolecules, smart biodelivery systems with tailored release kinetics, small molecule-membrane protein screening assays, in-vitro screens for the non-specific binding of drug molecules, the discovery of biomarkers and offer access to a new suite of quantitative dynamic molecular information.