IMPROVING ANIMAL RESOURCES FOR BIOMEDICAL RESEARCH

改善生物医学研究的动物资源

• 批准号: 3451098
• 负责人: HENRY J. BAKER
• 金额: $ 81.72万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1990-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3451098
• 关键词: Primates; Rodentias; animal care; animal colony; building /facility design /renovation; cats; dogs; isolation /quarantine; pigeons; sheep; swine; veterinary medicine; zoonosis

Wake Forest University (WFU) is a major biomedical research institution which sponsors 385 grants and contracts valued at more than $27 million dollars. Approximately half of all NIH supported projects at WFU use experimental animals. The Animal Resources Program (ARP) of WFU provides procurement, housing and care of all animals used in research, teaching and testing programs of the University. Currently, 150 investigators conducting 266 research projects with an aggregate value of $15.3 million dollars are supported by the ARP. Of 72,000 SF of animal resource space managed by the ARP, approximately 42,000 SF are located in buildings with architectural and mechanical characteristics which are unacceptable for contemporary animal research. This project will advance the quality of biomedical research at WFU by improving the ARP through the following specific aims. (1) Improve the environmental characteristics of 12,000 square feet (SF) of multipurpose animal resource space in the 25 year old Gray building to achieve compliance with standards of the Guide for the Care and Use of Laboratory Animals ("Guide") (DHEW Publication Number (NIH) 78-23, revised 1978) and meet the needs of WFU investigators. (2) Renovate 1,400 SF of animal resource space in the Gray building to isolate sheep used in perinatal biology research which will reduce exposure of personnel to zoonotic Q-fever. (3) Renovate seven primate housing buildings constructed between 1963 and 1977 (20,650 SF) to improve environmental characteristic, for housing 839 subhuman primates, many of which comprise a national resource colony. (4) Improve the 25 year old care and use facilities of an international resource pigeon colony of 1,200 birds. (5) Renovate a 6,000 SF dog housing facility and a 1,750 SF multipurpose facility on the Reynolda campus. (6) Purchase equipment necessary to (a) implement rigorous barrier maintenance of microbiologically defined rodents and rabbits, (b) improve housing of dogs, cats, rabbits, guinea pigs, and swine, (c) enhance the operation of diet preparation and cage sanitation facilities, and (d) improve emergency, preoperative, and postoperative care of animals.

维克森林大学（WFU）是一个主要的生物医学研究 该机构赞助了385笔赠款和合同，价值 超过2700万美元大约一半的NIH WFU支持的项目使用实验动物。 动物 WFU的资源计划（阿普）提供采购，住房 并照顾所有用于研究、教学和测试的动物 大学的方案。 目前，150名调查人员 进行266项研究计划，总值15.3元 100万美元由阿普提供。 72，000 SF动物 由阿普管理的资源空间，大约42，000 SF 位于建筑物内， 现代动物无法接受的特征 research. 该项目将提高生物医学的质量 在WFU进行研究，通过以下方式改进阿普 明确的目标。 (1)提升12,000平方环境特色 英尺（SF）的多用途动物资源空间在25岁 灰色建筑要达到符合《指南》标准 实验动物管理和使用指南（DHEW 出版号（NIH）78-23，1978年修订），并满足需要 WFU调查员 (2)在灰色地带改造1，400平方英尺的动物资源空间 一种用于围产期生物学研究的隔离羊舍， 将减少人员接触人畜共患Q热。 (3)翻修7座灵长类动物住房建筑 1963年至1977年（20，650平方英尺）， 有839种非人类灵长类动物，其中许多 构成了一个国家资源殖民地。 (4)改善25岁的护理和使用设施， 国际资源鸽群1,200只鸟。 (5)翻新一个6,000平方英尺的狗舍设施和一个1,750平方英尺的狗舍设施 多功能设施的校园。 (6)购买必要的设备，以（a）执行严格的 微生物确定的啮齿类动物的屏障维持， 兔，（B）改善狗、猫、兔、豚鼠的住房，和 猪，（三）加强饲料准备和笼子的操作 卫生设施，和（d）改善紧急情况，术前， 以及动物的术后护理。